外泌体在非小细胞肺癌转移中的作用及其机制

Role of exosomes in metastasis of non-small cell lung cancer and the underlying mechanisms

非小细胞肺癌(non-small cell lung cancer,NSCLC)常伴有不同器官转移。外泌体由活细胞分泌,可作为细胞与细胞之间信号传递的介质,参与机体病理生理过程,如肿瘤的上皮-间质转化、免疫抑制和逃逸、血管生成、炎症反应等,共同促进肿瘤转移。近年来大量研究表明,外泌体与NSCLC转移密切相关,尤其是外泌体在NSCLC迁移和侵袭潜力、免疫系统调节、转移前生态位形成方面具有重要作用。因此,对近年来外泌体在这几方面的作用及其机制的研究进展做一综述,有助于进一步了解外泌体在NSCLC发展中的作用。

Non-small cell lung cancer(NSCLC)is often diagnosed with different organ metastasis.Exosomes,secreted by living cells,are served as mediators in cell-to-cell communication and involved in pathophysiological processes including epithelial-mesenchymal transition,immunosuppression and immunologic escape,angiogenesis and inflammation,contributing to tumor progression.In recent years,accumulating evidence has implicated that exosomes are closely related to NSCLC metastasis,especially migration and invasion abilities,immunoregulation,and pre-metastatic niche formation.Here,we summarized the recent findings regarding the role of exosomes in these processes and the underlying mechanisms,contributing to the further understanding of the role of exosomes in the development of NSCLC.