HPV分型检测与TCT检测在宫颈病变筛查中的对比分析

Comparative analysis of HPV typing and TCT in cervical lesion screening

目的:探讨HPV分型检测与TCT检测在宫颈病变中的筛查价值。方法:选取HPV分型阳性患者和/或TCT阳性患者共1927例,均进行阴道镜及宫颈活检术。以宫颈活检结果即病理组织学检查为金标准,回顾性分HPV分型检测与TCT检测在宫颈病变筛查中的应用效果。结果:HPV分型检测的灵敏度为85.25%(185/217),漏诊率为14.75%(32/217),而TCT检测的灵敏度为76.96%,漏诊率为23.04%(50/217),两组灵敏度比较差异有统计学意义(χ^2=4.87,P<0.05),两组漏诊率比较差异有统计学意义(χ^2=4.87,P<0.05)。结论:HPV分型检测较TCT检测有更好的灵敏度,且漏诊率低,有望成为宫颈癌筛查的主要手段。

Objective:To investigate the screening value of HPV classification and TCT in cervical lesions.Methods:1927 patients of HPV positive and/or TCT positive were selected to test.Retrospective results of HPV classification test and TCT test in screening cervical lesions were obtained by using the results of cervical biopsy,namely pathological histology test,as gold standard.Results:The sensitivity of HPV was 85.25%(185/217),the rate of missed diagnosis was 14.75%(32/217),while the sensitivity of TCT was 76.96%and the rate of missed diagnosis was 23.04%(50/217).The difference in sensitivity between the two groups has statistically significantce(χ^2 value was 4.87,P<0.05)The difference in the rate of missed diagnosis between the two groups has statistically significance(χ^2 value was 4.87,P<0.05).Conclusion:HPV classification detection has better sensitivity than TCT detection,and the rate of missed diagnosis is low,which is expected to be the main method of cervical cancer screening.