急性ST段抬高心肌梗死患者PCI术后死亡危险因素分析及CTRP-1联合GRACE评分在预后评估中的价值

Risk Factors of Death in Patients with Acute ST-segment Elevation Myocardial Infarction after PCI and the Combined Application of CTRP-1 with GRACE Score in Prognosis Evaluation of PCI Treated Patients

目的探讨急性ST段抬高性心肌梗死(STEMI)患者经皮冠状动脉介入治疗术(PCI)出院后12个月内死亡的危险因素,以及炎症因子补体Cq1/肿瘤坏死因子相关蛋白1(CTRP-1)联合全球急性冠脉事件注册(GRACE)评分的危险分层对STEMI患者PCI术后出院12个月死亡风险的临床预测价值。方法回顾性连续纳入急性STEMI患者326例,死亡组33例,存活组293例。收集患者资料、酶联免疫吸附法(ELISA)检测的血清CTRP-1质量浓度资料,对所有患者进行GRACE评分。以随访期间患者心源性死亡作为终点事件,受试者工作曲线(ROC)评估CTRP-1预测死亡的最佳截点值,单因素及多因素Cox回归分析患者死亡危险因素,生存分析检验CTRP-1在GRACE评分基础上对急性STEMI患者死亡的预测价值。结果与存活组比较,死亡组患者平均动脉压、左心室射血分数(LVEF)低及左主干病变率高,肌酐、肌钙蛋白T较高(P<0.05),死亡组患者CTRP-1质量浓度高于存活组(P<0.001),死亡组患者中66.7%属于GRACE评分的高危组,高于存活组患者中20.1%属于GRACE评分的高危组。ROC曲线分析,CTRP-1的曲线下面积为0.874(P<0.001),其截点值为187.9 ng/mL时,预测患者死亡的敏感性为92.5%,特异度为73.6%。Cox生存回归分析显示,平均动脉压、LVEF值、GRACE评分高危及CTRP-1高值(≥187.9 ng/mL)是预测患者死亡的独立危险因素之一。生存分析显示,在GRACE评分高危组中,CTRP-1高值的患者累计生存率低于CTRP-1水平较低的患者(P<0.001)。结论平均动脉压、LVEF值、GRACE评分高危及CTRP-1高值是预测患者死亡的危险因素, CTRP-1联合GRACE评分对急性STEMI患者预后评估具有临床价值。

Objective To explore the risk factors of 12-month mortality in patients with acute ST-segment elevation myocardial infarction(STEMI) after percutaneous coronary intervention(PCI), and to evaluate the combined use of inflammatory factor complement Cq1/tumor necrosis factor-related protein-1(CTRP-1) with global acute coronary event registration(GRACE) score in the patients with STEMI after PCI in terms of prognostic prediction for 12-month mortality risk. Methods 326 acute STEMI patients were included retrospectively, with 33 patients in the death group and 293 patients in the survival group. Clinical data of patients and serum CTRP-1 concentration detected by enzyme-linked immunosorbent assay(ELISA) were collected, and all patients were evaluated by GRACE score. The cut-off point of CTRP-1 for predicting mortality was determined by receiver operating characteristic(ROC) curve. Cox regression model was used to analyze the risk factors of death. The predictive value of CTRP-1 combined with GRACE score was tested by Kaplan-Meier survival analysis. Results Compared with the survival group, the average arterial pressure, left ventricular ejection fraction(LVEF) and left main lesion rate were lower, creatinine and troponin T were higher in the death group(P<0.05). The mass concentration of CTRP-1 in the death group was higher than that in the survival group(P<0.001). The proportion of patients in the high-risk group of GRACE score was 66.7% in the death group and 20.1% in the survival group. The area under the ROC curve of CTRP-1 was 0.874(P<0.001), and the sensitivity and specificity of predicting death were 92.5% and 73.6% respectively with the cut-off point of CTRP-1 187.9 ng/mL. Cox regression model showed that mean arterial pressure, LVEF, GRACE score and high CTRP-1(>187.9 ng/mL) were independent risk factors for predicting death. Survival analysis showed that the cumulative survival rate of patients with high CTRP-1 level was lower than low CTRP-1 level in the high-risk group of GRACE score(P<0.001). Conclusions Mean arterial pressure, LVEF value, GRACE score and CTRP-1 are risk factors for predicting mortality. Combined application of CTRP-1 with GRACE score has clinical value in prognostic evaluation of acute STEMI patients.