神经酰胺Ⅱ脂质体的制备及在化妆品中的应用

Preparation of ceramide Ⅱ liposome and its application in cosmetics

通过乳化均质技术制备得到高含量(10%)神经酰胺Ⅱ脂质体,在偏光显微镜下观察到该脂质体粒径均一,具有大量的马耳他十字液晶结构;该神经酰胺Ⅱ脂质体稠度适宜,细腻光滑,稳定性好,水溶性好,通过简单搅拌即可应用到化妆品中,这在很大程度上解决了神经酰胺水溶性差,易结晶析出等问题。通过人体试验结果表明,使用添加1%神经酰胺Ⅱ脂质体(含10%神经酰胺Ⅱ)的乳霜,受试者的TEWL值(经表皮水分流失)在2h内可恢复85%,皮肤含水量在1h内增加39.58%,说明其具有良好的皮肤屏障修复性。

The liposome with high content(10%)of ceramideⅡwas prepared by the homogenization technique.A large number of Maltese Cross liquid crystal structures which were uniform in particle size were observed under a polarizing microscope.The ceramideⅡliposomes were smooth,soft and water-soluble,with suitable viscosity and good stability.It could be used in cosmetics by simply stirring,which solved the problems of poor water solubility and easy crystallization and precipitation for ceramide.Human-skin test results showed that the TEWLvalue(transepidermal water loss)of the subjects could recover 85%with the cream containing 1%ceramideⅡliposome(which contained 10%ceramideⅡ)in two hours,and the skin moisture content could be increased by 39.58%in an hour,which indicated that it had good repairing ability for skin barrier.