益气活血护心方对冠心病心绞痛的疗效及对患者心功能和VEGF的影响

Efficacy of Yiqi Huoxue Huxin Prescription on Coronary Heart Disease Angina Pectoris and Its Influence on Cardiac Function and VEGF

目的:探讨益气活血护心方对冠心病心绞痛的疗效及对患者心功能和血管内皮生长因子(VEGF)的影响。方法:选取2015年9月至2017年3月重庆三峡中心医院收治的冠心病心绞痛患者94例作为研究对象,按照随机数字表法分为对照组和观察组,每组47例,对照组采用常规西药治疗,观察组在此基础上增加益气活血护心方治疗。2个月后比较2组临床疗效、主要临床症状改善情况,治疗前后2组患者血清VEGF水平及心功能改善情况。结果:治疗后观察组总有效率为89.36%,明显高于对照组的72.34%(P<0.05)。治疗后2组患者临床症状总积分均明显降低,且观察组明显低于对照组(P<0.01)。与治疗前比较,治疗后2组患者血清VEGF水平及心功能指标CO、LVEF均明显升高,TFC及SVR均明显降低,且2组间差异有统计学意义(P<0.05或P<0.01)。结论:在常规西医治疗基础上增加益气活血护心方,可明显改善冠心病心绞痛患者临床症状,升高血清VEGF水平,改善心功能,提高总体临床疗效,改善患者预后。

Objective:To explore the efficacy of Yiqi Huoxue Huxin Prescription on coronary heart disease angina pectoris and its influence on cardiac function and vascular endothelial growth factor(VEGF).Methods:A total of 94 cases of coronary heart disease angina pectoris patients were selected and randomly divided into an observation group and a control group,with 47 cases in each group.The control group was treated with conventional western medicine,and the observation group added Yiqi Huoxue Huxin Prescription on the basis of control group.The clinical efficacy of 2 groups after treatment for 2 months were compared,and the improvement of main clinical symptoms,the serum VEGF level and cardiac function were compared in the 2 groups before and after treatment.Results:The total effective rate of the observation group was 89.36%,which was significantly higher than 72.34%of the control group(P<0.05).After treatment,the clinical symptoms scores of the 2 groups significantly decreased,and the observation group was significantly lower than that of the control group(P<0.01).Compared with before treatment,the serum VEGF level and cardiac function index CO,LVEF of the 2 groups significantly increased,TFC,SVR significantly decreased,and there was significant difference between the 2 groups(P<0.05 or P<0.01).Conclusion:Conventional western medicine add to Yiqi Huoxue Huxin Prescription can improve the clinical symptoms of patients with coronary heart disease angina pectoris,increase the serum VEGF level,improve the cardiac function of patients and overall clinical efficacy,improve the prognosis of patients.