摘要
活性氧可通过攻击损伤脱氧核糖核酸或核糖核酸造成细胞突变,诱导细胞癌变。Keap1-Nrf2/ARE是机体重要的氧化应激通路,Nrf2作为该系统的主效应因子,通过激活调控机体内多种Ⅱ相解毒酶的表达预防正常细胞恶变,发挥抗癌作用。有细胞及动物实验证明Nrf2可以促进肿瘤的发展,同时也能增加肿瘤细胞对化疗药物的耐受性。研究Keap1-Nrf2/ARE通路信号转导对于肿瘤的预防、发展和靶向治疗至关重要。
Reactive oxygen species can cause cell mutation and induce cell carcinogenesis by attacking deoxyribonucleic acid or ribonucleic acid.Keap1-Nrf2/ARE is an important oxidative stress pathway in the body.As the main effector of this system,Nrf2 can prevent malignant transformation of normal cells and play an anti-cancer role by activating and regulating the expression of various phaseⅡdetoxifying enzymes in the body.Cellular and animal experiments have shown that Nrf2 can promote the development of tumors and increase the tolerance of cancer cells to chemotherapeutic drugs.Research on signal transduction of Keap1-Nrf2/ARE pathway is essential for cancer prevention,development and targeted therapy.
作者
云图娅
苏秀兰
YUN Tuya;SU Xiulan(Clinical Medicine Research Center,Affiliated Hospital of Inner Mongolia Medical University,Inner Mongolia Autonomous Region,Hohhot 010030,China)
出处
《中国医药导报》
CAS
2019年第28期56-58,70,共4页
China Medical Herald
基金
国家自然科学基金资助项目（81660468）
