克洛己新干混悬剂治疗儿童急性化脓性扁桃体炎的临床效果

Clinical effect of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of acute suppurative tonsillitis in children

目的观察克洛己新干混悬剂治疗儿童急性化脓性扁桃体炎的临床效果。方法选取2017年6月~2018年6月就诊于昆明市儿童医院的急性化脓性扁桃体炎患儿120例,通过随机数字表法分成观察组(60例)和对照组(60例),分别给予克洛己新干混悬剂治疗和阿莫西林克拉维酸钾干混悬剂治疗,持续治疗7 d。比较两组临床疗效、症状体征消失时间、治疗前后扁桃体肿大分度及白细胞计数、中性粒细胞、C反应蛋白水平变化。结果观察组治疗总有效率明显高于对照组,差异有统计学意义(P<0.05)。观察组体温恢复正常、咽部充血消退、扁桃体脓性分泌物消失时间均明显短于对照组,差异有统计学意义(P<0.05)。观察组治疗后扁桃体肿大分度明显优于对照组,血清白细胞计数、中性粒细胞、C反应蛋白水平明显低于对照组,差异有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论克洛己新干混悬剂治疗儿童急性化脓性扁桃体炎症状消失快,疗效优于阿莫西林克拉维酸钾干混悬剂。

Objective To observe the clinical efficacy of Cefaclor and Bromhexine Hydrochloride for Suspension in the treatment of acute suppurative tonsillitis in children.Methods One hundred and twenty children with acute suppurative tonsillitis in Kunming Children′s Hospital from June 2017 to June 2018 were randomly divided into the observation group(60 cases)and the control group(60 cases)by random number table method,which were treated with Cefaclor and Bromhexine Hydrochloride for Suspension,Amoxicillin and Clavulanate Potassium Suspension,respectively.Both group continued treatment for 7 days.The clinical efficacy,disappearance time of symptoms and signs,the chamge of tonsil enlargement and white blood cell count,neutrophil and C-reactive protein levels before and after treatment were compared between the two groups.Results The total effective rate of treatment in the observation group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).The time of body temperature returning to normal,the disappearance of tonsil purulent secretion and the pharyngeal congestion of the observation group were significantly shorter than those of the control group,and the differences were statistically significant(P<0.05).After treatment,the tonsil enlargement of the observation group was significantly better than that of the control group,while serum white blood cell count,neutrophil and C-reactive protein levels in the observation were significantly lower than those in the control group,and the differences were statistically significant(P<0.05).There were no significant differences in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The treatment of acute suppurative tonsillitis inflammation in children with Cefaclor and Bromhexine Hydrochloride for Suspension is faster and better than Amoxicillin and Clavulanate Potassium Suspension.