探讨和分析帕金森病病患睡眠障碍的临床特征

To Explore and Analyze the Clinical Characteristics of Sleep Disorders in Patients with Parkinson’s disease (PD)

目的:观察帕金森病患者睡眠障碍临床特征。方法:选取2016年4月至2018年12月南通市第四人民医院神经内科收治的帕金森患者100例作为研究对象,按照是否存在睡眠障碍划分为观察组(n=70)与对照组(n=30),分析帕金森睡眠障碍者临床特征,并比较观察组与对照组患者ESS、PSQI评分。结果:帕金森睡眠障碍者主要临床症状有快速眼动睡眠期行为障碍、白天睡眠过渡、睡眠呼吸暂停综合征等。病程>5年、抑郁评分≥40分及左旋多巴胺每日用量>600 mg的帕金森病患者睡眠障碍发生率较高,差异有统计学意义(P<0.05),观察组与对照组PSQI评分存在明显差异,且观察组ESS评分比对照组高,差异有统计学意义(P<0.05)。结论:帕金森病患睡眠障碍有比较明显的临床特征,因此,设法改善患者睡眠,有利于改善患者自主神经功能障碍情况,提升患者的生命质量。

Objective:To observe the clinical features of sleep disorders in patients with Parkinson′s disease.Methods:100 patients with Parkinson′s disease admitted to our hospital from April 2016 to December 2018 were divided into observation group(n=70)and control group and control group(n=30)according to the presence or absence of sleep disorder.The clinical characteristics of patients with Parkinson′s sleep disorder were analyzed,and the ESS and PSQI scores of patients in study group and control group were compared.Results:The main clinical symptoms of Parkinson′s sleep disorder include active sleep behavior disorder,daytime sleep transition,sleep apnea syndrome,etc.The incidence rate of sleep disorders is higher in PD patients with disease course longer than 5 years,depression score≥40 points and daily dosage of levodopa greater than 600 mg,the difference is statistically significant(P<0.05).The PSQI score of the observation group and the control group are significantly different,and the depress score of the observatio group is higher than that of the control group,the difference is statistically significant(P<0.05).Conclusion:PD patients have obvious clinical features of sleep disorders.Therefore,trying to improve the sleep of patients is conducive to improving the autonomic nervous dysfunction of patients and improving the quality of life of patients.