阻塞性睡眠呼吸暂停低通气综合征伴咽喉反流性疾病采用奥美拉唑联合多潘立酮治疗的临床效果研究

Clinical Effects of Omeprazole Combined with Domperidone in Patients with Obstructive Sleep Apnea Hypopnea Syndrome and Pharyngeal Reflux Disease

目的:探讨奥美拉唑联合多潘立酮治疗阻塞性睡眠呼吸暂停低通气综合征伴咽喉反流性疾病的临床效果。方法:选取2018年1月至2019年1月山东省肥城市人民医院耳鼻喉科收治的阻塞性睡眠呼吸暂停低通气综合征伴咽喉反流性疾病患者40例作为研究对象,均接受奥美拉唑联合多潘立酮治疗,比较治疗前后症状改善情况。结果:治疗8周后RSI评分>13分,RFS评分>7分均,占10.0%,明显低于治疗前87.5%、92.5%,差异有统计学意义(P<0.05);治疗8周后AHI为(37.5±5.6)次/h,明显低于治疗前,差异有统计学意义(P<0.05)。结论:奥美拉唑联合潘多立酮治疗阻塞性睡眠呼吸暂停低通气综合征伴咽喉反流性疾病临床效果优良,值得推广。

Objective:To investigate the clinical effect of omeprazole combined with domperidone in the treatment of obstructive sleep apnea hypopnea syndrome(OSAHS)with pharyngeal reflux disease(LPRD).Methods:A total of 40 OSAHS patients with LPRD who were treated in our department of otolaryngology from January 2018 to January 2019 were selected,all of whom received omeprazole combined with domperidone to compare the improvement of symptoms before and after treatment.Results:RSI score>13 points and RFS score>7 points accounted for 10.0%after 8 weeks of treatment,which were significantly lower than 87.5%and 92.5%before treatment(P<0.05).AHI was(37.5±5.6)times/h 8 weeks after treatment,significantly lower than that before treatment(P<0.05).Conclusion:Prilosec combined with pantolidone has a good clinical effect in the treatment of OSAHS with LPRD.