从脂噬角度探讨补肾中药复方防治动脉粥样硬化的新策略

Discussion on the new strategy of Compound Chinese Medicine for Reinforcing Kidney for preventing and treating atherosclerosis from the perspective of lipophagy

动脉粥样硬化(AS)是与增龄密切相关的多因性疾病,脂质蓄积为其中关键的病理因素。脂噬作为自噬重要的亚进程,可通过溶酶体介导选择性降解细胞内脂滴,减少脂质沉积,从而成为AS研究的新靶点。秉承AS本虚标实的基本病机及病证结合的基本思路,基于自噬与脂质代谢在AS进程中的交互作用,结合补肾中药复方可有效延缓衰老、调节脂质代谢以干预治疗AS的前期研究结果,本文拟从脂噬角度进一步探讨补肾中药复方防治AS的研究策略。

Atherosclerosis(AS)is a multifactorial disease closely related to aging,and lipid accumulation is a key pathological factor.Lipophagy as an important sub-process of autophagy,it can selectively degradate intracellular lipid droplets via lysosome-mediated and reduce lipid deposition,which can be used as a new target for AS research.Adhering to the basic pathogenesis of deficient root and excessive branch,and the basic idea of the combination of disease and syndrome of AS,based on the interaction between autophagy and lipid metabolism in AS process,combined with the preliminary research results that the intervene therapy of AS,the Compound Chinese Medicine for Reinforcing Kidney can effectively delay aging and regulate lipid metabolism,this artical intends to further explore the research strategy of the Compound Chinese Medicine for Reinforcing Kidney prevents and treats AS from the perspective of lipophagy.