摘要
目的:探讨血小板参数与类风湿关节炎之间的关系。方法:采用回顾性分析方法选取2016年2月至2019年2月本院就诊的45例类风湿关节炎(RA)病人,另外选择60例健康体检志愿者。通过t-test比较血小板参数在两组人群间差异;结合RA相关临床指标,利用斯皮尔曼(Spearman)相关性分析,研究血小板参数与RA间的相关性。结果:与健康对照比较,血小板计数(PLT:)显著升高(P<0.05),而平均血小板体积(MPV)和血小板分布宽度(PDW)在RA患者中下调(f><0.05)。PLT与类风湿因子(R=0.437,P=0.007),血沉(R=0.371,P=0.016)和C反应蛋白(R=0.530,P<0.001)存在显著正相关。MPV与血沉(R=-0.403,P=0.012)和C反应蛋白(R=-0.375,P=0.022)负相关。PDW与血沉(R=-0.447,P=0.005)和C反应蛋白(R=-0.509,P=0.001)负相关。抗环瓜安酸肽抗体与血小板各参数间皆不存在相关性。结论:RA患者血小板参数出现异常,并与RA相关的临床特征存在显著相关,对提高RA临床诊断具有重要意义。
Objective:To investigate the correlation of platelet parameters and rheumatoid arthritis(RA).Methods:RA patients(N=45)and healthy controls(N=60)were collected and analyzed from February 2016 to February 2019 by using a retrospective study.The difference of platelet parameters were compared between two groups with t-test The correlation of platelet parameters and RA were investigated with Spearman correlation study.Results:Compared with health controls,PLT was higher,while MPV and PDW were lower in RA patients.PLT was positively correlated with RF(R=0.437,P=0.007),ESR(R=0.371,P=0.016)and CR P(R=0.530,P<0.001).However,MPV was negatively correlated with ESR(R=-0.403,P=0.012)and CRP(R=—0.375,P=0.022).Similarly,PDW was also correlated with ESR(R=-0.447,P=0.005)and CRP(R=—0.509,P=0.001).CCP has no relationship with platelet parameters.Conclusion:Platelet parameters were different in RA patients compared with the healthy control,and correlated with RA clinic characteristics.Thisresult will provide insight into improving RA clinic diagnosis.
作者
秦跃红
吕心路
曹季军
QIN Yue-hong;LV Xin-lu;CAO Ji-jun(Department of Clinical Laborator,First People's Hospital of Taicang,Jiangsu Taicang 215400)
出处
《医学检验与临床》
2019年第9期17-19,共3页
Medical Laboratory Science and Clinics
关键词
类风湿关节炎
血小板
诊断
Rheumatoid arthritis
Platelet parameters
Diagnosis