地西他滨联合CAG方案治疗老年急性髓系白血病的Meta分析

Decitabine combined with CAG regimen in treatment of elderly patients with acute myeloid leukemia:a Meta analysis

目的应用Meta分析方法,综合评价地西他滨联合CAG方案治疗老年急性髓系白血病的临床疗效及安全性。方法利用计算机对Cochrane Library、Pubmed、中国期刊全文数据库(CNKI)、万方数据库、维普数据库等进行文献检索、筛选,对纳入文献进行方法学质量评估后提取数据,通过Stata13.0统计软件进行分析。结果共纳入12篇文献(均为随机对照试验),合计814例患者。其中试验组(地西他滨联合CAG方案)410例,对照组(CAG方案)404例。治疗后试验组总有效率和完全缓解率均显著高于对照组(P<0.05)。试验组肺部感染、发热发生率高于对照组(P<0.05),血小板减少发生率低于对照组(P<0.05)。结论地西他滨联合CAG方案明显改善了老年急性髓系白血病患者的临床疗效,但可能增加了肺部感染、发热等药物相关不良反应的发生。

Objective To comprehensively evaluate the efficacy and safety of decitabine combined with CAG regimen on elderly patients with acute myeloid leukemia by using the Meta-analysis method.Methods The literature retrieval and screening were conducted in the Cochrane Library,Pubmed,CNKI,Wanfang database and Vip database by computer.Then the included literatures conducted the methodological quality evaluation,then the data were extracted and analyzed by using Stata13.0 statistical software.Results Twelve articles(randomized controlled trials)were included involving 814 patients,in which the experimental group(decitabine combined with CAG regimen)had 410 cases,and the control group(CAG rgimen)had 404 cases.After treatment,ORR and CR of the experimental group were significantly higher than those of the control group(P<0.05).But the occurrence rates of pulmonary infection and fever in the experimental group were higher than those in the control group(P<0.05).The occurrence rate of thrombocytopenia in the experimental group was lower than that in the control group(P<0.05).Conclusion Decitabine combined with CAG regimen significantly improve the clinical effect in elderly patients with acute myeloid leukemia,but may increase the occurrence of drug related adverse reactions such as pulmonary infection and fever.