超敏C反应蛋白、IL-6、TNF-α水平与2型糖尿病酮症酸中毒继发感染的相关性

Correlation between high-sensitivity C-reactive protein,IL-6,TNF-αlevels and secondary infection with type 2 diabetic ketoacidosis

目的探讨超敏C反应蛋白(hs-CRP)、细胞因子[白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α]水平与2型糖尿病酮症酸中毒(DKA)继发感染的相关性。方法选取该院2016年1月至2018年12月收治的60例DKA继发感染患者纳入DKA感染组,另选取同期在该院接受治疗的60例DKA非感染患者纳入DKA非感染组,分别对两组患者的hs-CRP、IL-6、TNF-α进行检测,分析hs-CRP、IL-6、TNF-α水平与DKA患者继发感染的相关性。结果与DKA非感染组比较,DKA感染组患者hs-CRP、IL-6、TNF-α水平明显升高,差异均有统计学意义(P<0.05)。hs-CRP、IL-6、TNF-α水平与DKA患者继发感染均呈相关性(r=0.412、0.387、0.359,P<0.05)。结论hs-CRP、IL-6、TNF-α与DKA患者继发感染具有明显相关性。加强对hs-CRP、IL-6、TNF-α的动态监测可为临床DKA的防治提供更多参考依据,有利于提高医生对DKA继发感染患者的临床诊治水平。

Objective To investigate the correlation between high-sensitivity C-reactive protein(hs-CRP),cytokines(IL-6,TNF-α)and secondary infection of type 2 diabetic ketoacidosis(DKA).Methods Sixty cases of DKA secondary infection admitted to the hospital from January 2016 to December 2018 were selected as the DKA infection group.And other 60 cases of DKA non-infection treated in the hospital during the same period were included as the DKA non-infection group.The levels of hs-CRP,IL-6 and TNF-αin the two groups were detected.Then the correlation between hs-CRP,IL-6 and TNF-αwith secondary infection in DKA patients was analyzed.Results The levels of hs-CRP,IL-6 and TNF-αin the DKA infection group were higher than those in the DKA non-infection group,and the difference was statistically significant(P<0.05).Hs-CRP,IL-6 and TNF-αwere correlated with DKA secondary infection(r=0.412,0.387,0.359,P<0.05).Conclusion The levels of hs-CRP,IL-6 and TNF-αhave the correlation with DKA secondary infection.Strengthening the dynamic detection of hs-CRP,IL-6 and TNF-αcan provide more reference basis for the prevention and treatment of DKA,and help to improve the clinical treatment level of DKA patients with secondary infection.