益生菌对Ⅱ型糖尿病影响的研究进展

Recent Advances in Understanding of the Potential Impact of Probiotics on Type Ⅱ Diabetes

肠道菌群在调节机体新陈代谢、维持人体健康和疾病发生中起着重要作用。近年来随着对肠道微生物研究的深入,人们发现肠道菌群与代谢综合征、过敏、神经退行性疾病等疾病的发生和发展密切相关。目前,肠道菌群与人体健康之间的联系成为研究热点,但肠道菌群与这些疾病的关系以及相应的发病机制尚不清楚。对肠道菌群结构和代谢物的16S rRNA及宏基因组进行分析,揭示了肠道菌群组成与糖尿病之间的相关性。益生菌作为人体肠道共生菌中一类特殊的菌群,可以调节胃肠道稳态、营养物质代谢和能量平衡。因此,以肠道微生物为靶点缓解或治疗糖尿病有其独特的优势。本文总结了益生菌在糖尿病防治中的研究进展,为糖尿病的相关研究提供参考。

The gut microbiota play an important role in metabolism, maintaining human health and developing disease. In recent years, a series of studies on the gut microbiota have demonstrated that the intestinal flora is closely related to the occurrence and development of some metabolic syndromes(obesity, diabetes, and high blood pressure), allergic reactions, and neurodegenerative diseases. The relationship between the intestinal flora and human health has become a research hotspot, but the relationship between the gut microbiota and these diseases and the pathogenic mechanisms are still unclear. At present, 16 S rRNA and macrogenomic analysis of intestinal flora structure and metabolites reveal the correlation between intestinal microorganisms and diabetes mellitus. As a special group of intestinal symbiotic bacteria, probiotics play an important role in regulating gastrointestinal homeostasis, nutrient metabolism and energy balance. Potential therapeutic strategies targeting the gut microbiota for diabetes have their unique advantages. This paper summarizes the recent progress in the application of probiotics in the prevention and treatment of diabetes, which will provide useful information for further research on diabetes.