冠心病患者血清visfatin水平与氧化应激及颈动脉粥样硬化的关系

Relationship between serum visfatin level and oxidative stress and carotid atherosclerosis in patients with coronary heart disease

目的研究冠心病患者血清内脏脂肪素(visfatin)水平与氧化应激及颈动脉粥样硬化的关系。方法选择2017年1月~2018年1月厦门大学附属成功医院(以下简称“我院”)收治的冠心病患者80例作为研究组,根据Gensini积分将患者分为轻度动脉硬化组(29例)、中度动脉硬化组(25例)、重度动脉硬化组(26例)。按照性别、年龄、血压、血糖、血脂匹配选择我院同期收治的非冠心病患者80例作为对照组。分别比较两组各项生化指标、血清visfatin、丙二醛(MDA)、超氧化物歧化酶(SOD)水平,分析SOD、MDA、颈动脉粥样硬化严重程度与血清visfatin水平的关系。结果两组血压、血糖、血脂水平差异无统计学意义(P>0.05)。研究组血清visfatin、MDA显著高于对照组,血清SOD显著低于对照组,差异有统计学意义(P<0.05)。中度动脉硬化组visfatin、MDA显著高于轻度动脉硬化组,SOD低于轻度动脉硬化组,差异有统计学意义(P<0.05)。重度动脉硬化组visfatin、MDA显著高于轻度和中度动脉硬化组,SOD显著低于轻度和中度动脉硬化组,差异有统计学意义(P<0.05)。冠心病患者血清visfatin水平与血清MDA水平、Gensini积分呈正相关(r=0.587、0.634,P<0.05),与SOD水平呈负相关(r=-0.609,P<0.05)。结论冠心病患者血清visfatin水平存在明显高表达,且与氧化应激与颈动脉粥样硬化密切相关。临床工作中可通过对血清visfatin水平进行检测,从而有利于评估患者氧化应激状态与颈动脉粥样硬化严重程度,值得临床推广应用。

Objective To study the relationship between serum visfatin level and oxidative stress and carotid atherosclerosis in patients with coronary heart disease.Methods Eighty patients with coronary heart disease admitted to Success Hospital Affiliated to Xiamen University(“our hospital”for short)from January 2017 to January 2018 were selected as the study group.According to Gensini scores,the patients were divided into mild atherosclerosis group(29 cases),moderate atherosclerosis group(25 cases)and severe atherosclerosis group(26 cases).While matching of sex,age,blood pressure,blood sugar and blood lipid,eighty patients with non-coronary heart disease admitted to our hospital during the same period were selected as the control group.The levels of biochemical indicators,serum visfatin,malondialdehyde(MDA)and superoxide dismutase(SOD)were compared between the two groups,respectively.And the relationship between SOD,MDA and the severity of carotid atherosclerosis and the level of serum visfatin were analyzed.Results There were no statistically significant differences in blood pressure,blood sugar and blood lipid between the two groups(P>0.05).The serum visfatin and MDA in the study group were significantly higher than those in the control group,while the serum SOD in the study group was significantly lower than that in the control group,and the differences were statistically significant(P>0.05).Serum visfatin and MDA levels in mild atherosclerosis group were higher than those in moderate atherosclerosis group,while SOD levels were lower than that in mild atherosclerosis group,and the differences were statistically significant(P<0.05).Serum visfatin and MDA levels in severe atherosclerosis group were statistically higher than those in mild and moderate atherosclerosis group,while SOD levels was lower than that in mild and moderate atherosclerosis group,and the differences were statistically significant(P<0.05).Serum visfatin levels were positively correlated with serum MDA levels and Gensini score(r=0.587,0.634,P<0.05),while negatively correlated with SOD levels(r=-0.609,P<0.05).Conclusion The serum visfatin levels in patients with coronary heart disease are significantly higher and closely related to oxidative stress and carotid atherosclerosis.Serum visfatin level can be detected in clinical work,which is helpful to assess oxidative stress and severity of carotid atherosclerosis.It is worthy of clinical application.