非编码RNAs在人牙髓干细胞中的调控作用及机制

Non-coding RNAs in human dental pulp stem cells: regulations and mechanisms

背景:人牙髓干细胞是一种重要的口腔间充质干细胞,具有很强增殖和多向分化能力。随着人类基因组计划的不断深入,人们逐渐意识到功能性非编码RNAs在调节基因表达方面有着至关重要的作用。目的:对非编码RNAs在人牙髓干细胞中的研究进展进行论述。方法:由第一作者以“ncRNAs,human dental pulp stem cell,regenerative medicine”为英文关键词,以“长链非编码RNAs,人牙髓干细胞,再生医学”为中文关键词,检索2005至2019年期间收录在PubMed、Medline、中国知网、万方等数据库中的文献,排除与文章研究目的无关及重复性的文献,纳入符合标准的71篇文献进行综述。结果与结论:目前普遍认为,非编码RNAs可以作为特定细胞状态的信号,为临床提供预后价值,甚至为患者提供治疗选择。随着再生医学应用的不断发展,人牙髓干细胞将越来越受到关注,研究非编码RNAs与人牙髓干细胞的关系,将为人牙髓干细胞的临床应用研究寻觅了一条新的途径。

BACKGROUND:Human dental pulp stem cells are important oral mesenchymal stem cells with strong proliferation and multidirectional differentiation functions.In-depth studies on the Human Genome Project make people gradually realize that functional non-coding RNAs play an extraordinary role in regulating gene expression.OBJECTIVE:To discuss the function and application of non-coding RNAs in human dental pulp stem cells.METHODS:Using“ncRNAs,human dental pulp stem cells,regenerative medicine”as keywords in English and Chinese,the first author searched PubMed,Medline,CNKI,and WanFang for relevant articles published from 2005 to 2019.Literatures unrelated to the purpose of the study and repetitive literatures were excluded,and 71 articles that meet the criteria were included for review.RESULTS AND CONCLUSION:It is now generally believed that non-coding RNAs can be used as a signal of specific cell state,providing prognostic value and even providing treatment options for patients.With the continuous development of regenerative medicine applications,human dental pulp stem cells are arousing increasing attentions.Exploration on the relationship between non-coding RNAs and human dental pulp stem cells provides a new approach for the clinical application of human dental pulp stem cells.