奥氮平血药浓度与细胞色素P4501A2基因多态性关系的meta分析

Association of serum olanzapine concentration and c ytochrome P450 1A2 gene polymor phisms: a meta-analysis

目的·研究细胞色素P4501A2(CYP1A2)基因多态性与奥氮平血药浓度变化之间的关系。方法·以关键词“CYP1A2”“基因多态性”“精神分裂症”“奥氮平”“血药浓度”检索SinoMed、万方、维普、中国知网、PubMed、Embase、Cochrane Library数据库,检索时间段限定为建库至2018年2月27日,并利用STATA/SE 12.0软件进行统计分析。结果·最终纳入4项病例对照研究,包括330例精神分裂症患者。在CYP1A2基因的-163C>A位点隐性模型(A/A vs C/A+C/C)中,携带纯合突变基因型A/A的患者与携带C/A或C/C基因型的患者相比,其奥氮平血药浓度/剂量比(concentration/dosage ratio,C/D)显著降低。结论·CYP1A2基因-163C>A位点的A/A纯合基因型与奥氮平C/D比值降低具有显著相关性。

Objective·To investigate association of cytochrome P4501A2(CYP1A2)gene polymorphisms and serum olanzapine concentration.Methods·Key words including“cytochrome P450 CYP1A2”,“genetic polymorphism”,“antipsychotic”,“olanzapine”,“schizophrenia”,and“serum concentration”were used to search in databases,including SinoMed,Wanfang,Weipu,CNKI,PubMed,Embase and Cochrane Library.The search period was limited from the establishment of the database to February 27^th,2018.STATA/SE 12.0 package was applied to conduct statistical analyses.Results·Four studies with a total of 330 schizophrenic patients were included.In the recessive model of CYP1A2 gene-163C>A SNP,patients with A/A genotype had significantly lower olanzapine concentration/dosage ratio(C/D)than patients with C/C or C/A genotype.Conclusion·A/A homozygote of CYP1A2 gene-163C>A SNP is significantly associated with the decreased olanzapine serum concentration.