外周血内PCT、CRP、ESR、PLT水平对炎症性肠病的预判价值分析

Analysis of the predictive value of PCT,CRP,ESR and PLT levels in peripheral blood for inflammatory bowel disease

目的分析外周血降钙素原(PCT)、C反应蛋白(CRP)、红细胞沉降率(ESR)、血小板计数(PLT)对炎症性肠病(IBD)的预判价值,为IBD的临床诊断及病情了解提供参考依据。方法收集徐州医科大学附属市立医院消化内科住院并明确诊断为IBD的患者85例,其中溃疡性结肠炎患者40例,克罗恩病患者45例,同时选取25例门诊体检健康者作为健康对照组。根据克罗恩病活动指数和Mayo评分系统评估克罗恩病和溃疡性结肠炎疾病活动性。用相应方法检测IBD患者及健康对照组人群的外周血PCT、CRP、ESR、PLT的水平,比较各标志物在IBD患者不同时期及健康对照组之间的差异,采用Spearman相关分析法分析各标志物与IBD患者临床疾病活动性评分的相关性。结果与健康对照组比较,IBD患者外周血PCT、CRP、ESR、PLT水平均有所升高,差异有统计学意义(P<0.05)。与疾病缓解期比较,轻度活动期PCT、CRP、ESR、PLT水平升高,差异有统计学意义(P<0.05);中重度活动期PCT、CRP、ESR、PLT水平又明显高于轻度活动期患者,差异有统计学意义(P<0.05)。IBD患者疾病的严重程度与其外周血PCT、CRP、ESR、PLT水平呈正相关。结论外周血PCT、CRP、ESR、PLT水平可作为判断IBD患者临床疾病活动度的可靠、非侵入性生物标志物,在评价IBD患者病情中具有重要价值。

Objective To analyze the predictive value of procalcitonin(PCT),C-reactive protein(CRP),erythrocyte sedimentation rate(ESR)and platelet count(PLT)in patients with inflammatory bowel disease(IBD),so as to provide reference for clinical diagnosis and understanding of IBD.Methods Totally 85 cases of IBD were collected,including 40 cases of ulcerative colitis and 45 cases of Crohn′s disease,25 healthy outpatients were selected as the healthy control group.The activity of Crohn′s disease and ulcerative colitis was evaluated according to Crohn′s disease activity index and Mayo scoring system.The levels of PCT,CRP,ESR and PLT in peripheral blood of IBD patients and healthy control group were measured by corresponding methods,and the differences of each marker in different periods of IBD patients and healthy control group were compared.The correlation between each marker and clinical disease activity score of IBD patients was analyzed by Spearman correlation analysis.Results Compared with the healthy control group,the levels of PCT,CRP,ESR and PLT in the peripheral blood of IBD patients were increased,the difference was statistically significant(P<0.05).Compared with the remission stage,the levels of PCT,CRP,ESR and PLT in the mild active stage increased significantly(P<0.05);the levels of PCT,CRP,ESR and PLT in the moderate and severe active stage were significantly higher than those in the mild active stage(P<0.05).The severity of IBD was positively correlated with PCT,CRP,ESR and PLT.Conclusion The levels of PCT,CRP,ESR and PLT in peripheral blood can be used as reliable and non-invasive biomarkers to judge the clinical disease activity of IBD patients,and have important value in the evaluation of IBD patients.