右美托咪定对心脏手术患者术后房颤的预防作用

Preventive effect of dexmedetomidine on postoperative atrial fibrillation in patients undergoing cardiac surgery

目的探讨右美托咪定对心脏手术患者术后新发房颤的预防作用。方法选取2018年1月~2019年1月期间收治的体外循环心脏手术术后患者108例,按照术后镇静药物不同随机分为右美托咪定组(n=52)和丙泊酚组(n=56),分析两组患者术后96 h内的房颤发生率、术后住ICU时间、住院时间和费用等指标的差异。结果右美托咪定组术后房颤发生率为15.4%,低于丙泊酚组(35.7%),差异有统计学意义(P=0.014)。右美托咪定组术后住ICU时间为(5.7±0.8)d,低于丙泊酚组的(8.6±1.3)d,差异有统计学意义(P<0.001)。结论右美托咪定在心脏手术后新发房颤的预防作用明显,可有效缩短入住ICU时间。

Objective To investigate the preventive effect of dexmedetomidine on postoperative new atrial fibrillation in patients undergoing cardiac surgery.Methods A total of 108 patients undergoing cardiopulmonary bypass surgery between January 2018 and January 2019 were randomly divided into dexmedetomidine group(n=52)and propofol group(n=56)according to postoperative sedative drugs.Differences in the incidence of atrial fibrillation in postoperative 96 hours,postoperative ICU time,length of hospital stay and cost between two groups were analyzed.Results The incidence of postoperative atrial fibrillation was 15.4%in the dexmedetomidine group,lower than that in the propofol group(35.7%).The difference was statistically significant(P=0.014).The ICU time in the dexmedetomidine group was(5.7±0.8)days,which was lower than that in the propofol group(8.6±1.3 days).The difference was statistically significant(P<0.001).Conclusion The dexmedetomidine on the prevention of new atrial fibrillation after cardiac surgery has obvious effect,which can effectively shorten the time of staying in ICU.