摘要
糖基转移酶(Glycosyltransferases,GTs;EC 2.4.x.y)是能催化特定的糖与受体之间形成糖苷键的一个多成员的转移酶家族。根据其氨基酸序列的相似性、底物特异性以及催化特异性可分为106个(GT1~GT106)不同的家族。GTs以不同的糖基为供体,催化糖分子转移到受体分子上,可以调节受体分子的理化性质进而调节其生物活性。GTs在次生代谢产物的糖基化修饰、內源或外源物质的解毒、机体防御、激素调节等方面发挥着重要作用。本文对糖基转移酶的命名、分类、结构、生物功能以及应用等方面展开综述,以期为糖基转移酶相关研究提供参考。
Glycosyltransferases(GTs;EC 2.4.x.y)belong to a multi-member genes family and are categorized into 106 subfamilies basing on their amino acid sequences and catalytic specificity.GTs catalyze the covalent combination of sugar and specific acceptor named as glycosidic bonds.The glycosyl donors usually are nucleotide diphospho-sugar,nucleotide monophospho-sugar and sugar phosphates,regulating the water solubility and biological activity.GTs play an important role in glycosylation,plant hormone balance,detoxification and defense reaction of secondary metabolites.In this paper,we reviewed the nomenclature,classification,function and application of GTs to provide some references for related research.
作者
马风伟
邓青芳
陈海江
程永友
许粟
MA Feng-wei;DENG Qing-fang;CHEN Hai-jiang;CHENG Yong-you;XU Su(Food and Pharmaceutical Engineering Institute,Guiyang University,Guizhou Guiyang 550005,China;Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment of Guizhou Province,Guizhou Normal University,Guizhou Guiyang 550001,China)
出处
《贵阳学院学报（自然科学版）》
2019年第3期73-82,共10页
Journal of Guiyang University：Natural Sciences
基金
贵州省科技厅基础研究计划项目(项目编号:黔科合基础[2019]1013号)
贵州省教育厅青年科技人才成长项目(项目编号:黔教合KY字[2018]291,黔教合KY字[2018]303)
贵阳学院博士科研启动经费项目(项目编号:GYU-ZRD[2018]-022,GYU-ZRD[2018]-029)
贵阳市科技局贵阳学院专项资金(项目编号:GYU-KYZ[2018]01-13,GYU-KYZ[2018]01-16,GYU-KYZ[2018]01-20,GYU-KYZ[2018]01-26)
关键词
糖基转移酶
命名
分类
功能
应用
Glycosyltransferase
Nomenclature
Classification
Function
Application
