丙型肝炎病毒生活周期中脂蛋白代谢的研究进展

Research progress on lipoprotein metabolism in the hepatitis C virus life cycle

丙型肝炎病毒(HCV)是包括肝细胞癌在内的慢性肝病的重要病因。由于HCV缺乏进行自身脂质合成的途径,因此进化出了利用宿主脂质代谢来完成胞内病毒复制的过程。脂蛋白是运输脂质的载体,甘油三酯、游离胆固醇、胆固醇酯和磷脂是脂质转运的主要成分。越来越多的研究证明,HCV生活周期中的入胞、复制、装配和排出的各个阶段均与脂蛋白的代谢密切相关,而介导这一相互作用的关键分子是载脂蛋白。了解HCV生活周期和脂蛋白代谢有利于发现抗HCV治疗的潜在靶点和指导疫苗的设计工作。本文就HCV生活周期与脂蛋白代谢之间的关联作一综述。

Hepatitis C virus(HCV)is an important cause of chronic liver disease,including HCC.Due to the lack of self lipid synthesis pathway,HCV has evolved the process of using host lipid metabolism to complete the replication of intracellular virus.Lipoproteins are the carriers of lipid transport.Triglycerides,free cholesterol,cholesterol esters and phospholipids are the main components of lipid transport.More and more studies have shown that all stages of the entry,replication,assembly and excretion of HCV life cycle are closely related to the metabolism of lipoproteins,and the key molecule mediating this interaction is apolipoproteins.Therefore,understanding the life cycle and lipoprotein metabolism of HCV is helpful to find potential targets of anti HCV therapy and guide the design of vaccine.In this review,we summarized the studies on the relationship between HCV life cycle and lipoprotein metabolism.