痰热清注射液对痰浊壅肺型慢性阻塞性肺疾病急性加重期患者肺血管阻力和氧化应激指标的影响

Effect of Tanreqing Injection on pulmonary vascular resistance and oxidative stress in patients with acute exacerbation of chronic obstructive pulmonary disease of phlegm turbid lung type

目的:探讨痰热清注射液对痰浊壅肺型慢性阻塞性肺疾病急性加重期(AECOPD)肺血管阻力、氧化应激指标的影响。方法:选择我院收治的AECOPD患者121例,按随机数字表法分为观察组和对照组,对照组给予常规治疗,观察组给予痰热清注射液治疗,评估疗效并比较患者肺功能、血气分析、肺动脉收缩压、肺血管阻力及氧化应激指标。结果:观察总有效率显著高于对照组。治疗后观察组FVC、FEV1、FEV1/FVC显著高于对照组。治疗后2组PH值无显著变化,PaO2较治疗前显著升高,PaCO2较治疗前显著降低,且观察组改善程度显著优于对照组。治疗后观察组PASP、PVR低于对照组,观察组SOD高于对照组,MDA低于对照组,且观察组改善程度显著优于对照组,观察组患者的发热、咳嗽、气喘、腹胀等中医证候评分均低于对照组。结论:痰热清注射液治疗痰浊壅肺型AECOPD患者可有效改善患者临床症状,提高临床疗效,并有助于改善患者血气分析及肺功能,值得临床推广运用。

Objective:To investigate the effect of Tanreqing injection on pulmonary vascular resistance and oxidative stress in acute exacerbation of chronic obstructive pulmonary disease(AECOPD).Methods:121 patients with AECOPD admitted to our hospital were randomly divided into observation group and control group.The control group was given routine treatment,while the observation group was given Tanreqing injection.Pulmonary function,blood gas analysis,pulmonary artery systolic pressure,pulmonary vascular resistance and oxidative stress were evaluated and compared.Results:The total effective rate of observation was significantly higher than that of control group.After treatment,FVC,FEV1 and FEV1/FVC in the observation group were significantly higher than those in the control group.After treatment,the PH value of the two groups did not change significantly,PaO2 increased significantly,PaCO2 decreased significantly,and the improvement degree of the observation group was significantly better than that of the control group.After treatment,PASP and PVR in the observation group were lower than those in the control group.SOD in the observation group was higher than that in the control group,MDA was lower than that in the control group,and the improvement in the observation group was significantly better than that in the control group.The scores of fever,cough,asthma and abdominal distension in the observation group were lower than those in the control group.Conclusion:Tanreqing injection can effectively improve the clinical symptoms and clinical efficacy of patients with phlegm turbid obstruction of lung type AECOPD,and help to improve the blood gas analysis and pulmonary function of patients,which is worthy of clinical application.