摘要
以金鸡纳碱衍生的双功能方酰胺为催化剂,催化苄醇与吡唑啉酮亚胺的不对称加成反应,以高达85%的收率和92%ee合成了12个结构新颖的含有吡唑啉酮骨架的N,O-缩醛类手性化合物,其结构经1H NMR,13C NMR,HR-MS(ESI-TOF)及X-ray表征。
An organocatalytic asymmetric addition of phenylmethanol with pyrazolone derived N-Boc ketimines catalyzed by cinchona-derived bifunctional squaramid has been developed.With this protocol,a series of chiral compounds bearing pyrazolone and N,O-acetal skeletons were obtained in good yields(up to 85%)and high enantioselectivities(up to 92%ee).The structures were characterized by 1 H NMR,13 C NMR,HR-MS(ESI-TOF)and X-ray.
作者
周扬
周鸣强
袁伟成
ZHOU Yang;ZHOU Ming-qiang;YUAN Wei-cheng(National Engineering Research Center of Chiral Drugs,Chengdu Institute of Organic Chemistry,Chinese Academy of Sciences,Chengdu 610041,China)
出处
《合成化学》
CAS
北大核心
2019年第11期873-877,共5页
Chinese Journal of Synthetic Chemistry
基金
国家自然科学基金资助项目(21602217)
中国科学院西部之光青年学者项目
关键词
N
O-缩醛
有机催化
苄醇
吡唑啉酮亚胺
合成
N,O-acetals
organocatalytic
phenylmethanol
pyrazolinone ketimine
synthesis
