单孔悬吊式腹腔镜手术结合GnRh-α对卵巢子宫内膜异位囊肿患者AMH及HMGB1与RBP4的影响

Effect of single-hole suspension laparoscopic surgery combined with GnRh-α on AMH, HMGB1 and RBP4 in patients with ovarian endometriosis

目的探讨单孔悬吊式腹腔镜手术结合GnRh-α对卵巢子宫内膜异位囊肿患者AMH、HMGB1及RBP4的影响。方法选取本院2016年6月至2017年10月收治的86例卵巢子宫内膜异位囊肿患者,根据治疗方案不同分为观察组与对照组,各43例。两组患者均接受单孔悬吊式腹腔镜手术治疗,观察组患者给予GnRh-α。对两组患者手术情况、AMH、HMGB1及RBP4水平进行比较。结果观察组腹腔引流量、术后肛门排气时间与对照组比较差异具有统计学意义(P<0.05);两组患者术前AMH、MHGB1、RBP4水平对比差异无统计学意义,观察组术后AMH、MHGB1、RBP4水平明显低于对照组(P<0.05)。结论单孔悬吊式腹腔镜手术结合GnRh-α能缩短术后排气时间,利于患者术后康复,能抑制AMH、HMGB1、RBP4表达,值得临床推广应用。

Objective To investigate the effect of single hole suspension laparoscopic surgery combined with GnRh-α on AMH, HMGB1 and RBP4 in patients with ovarian endometriosis cyst. Methods 86 patients with ovarian endometriosis cysts treated in our hospital from June 2016 to October 2017 were divided into observation group and control group, with 43 cases in each group. Both groups received single-hole suspension laparoscopic surgery, and the observation group received GnRh-α. Comparison of surgical conditions, AMH, HMGB1 and RBP4 levels in the two groups. Results The difference of abdominal drainage volume and postoperative exhaust time between the observation group and the control group was statistically significant(P<0.05);Before surgery, the preoperative AMH, MHGB1, RBP4 level of the two groups had no significant difference, and the AMH, MHGB1, RBP4 level in the observation group were significantly lower than those in the control group after surgery(P<0.05). Conclusion Single hole suspension laparoscopic surgery combined with GnRh-α can shorten the postoperative exhaust time, benefit the patients’ recovery after operation, and inhibit the expression of AMH, HMGB1 and RBP4, which is worth popularizing.