普瑞巴林联合泼尼松对带状疱疹后遗神经痛患者免疫功能的影响

Effect of Pregabalin Combined with Prednisone on Immune Function in Patients with Postherpetic Neuralgia

目的:观察普瑞巴林联合泼尼松对带状疱疹后遗神经痛患者免疫功能和炎性因子的影响,并探讨其机制。方法:选取带状疱疹后遗神经痛患者135例为研究对象,随机分为泼尼松组(单用泼尼松治疗)、普瑞巴林组(单用普瑞巴林治疗)和联合治疗组(普瑞巴林联合泼尼松治疗),每组各45例。比较3组T淋巴细胞亚群(CD3^+、CD4^+、CD8^+、CD4^+/CD8^+)、炎性因子[白介素2(IL-2)、白介素6(IL-6)、白介素10(IL-10)、肿瘤坏死因子α(TNF-α)]、疼痛物质[神经肽Y(NPY)、P物质(SP)]、神经元特异性烯醇化酶(NSE)、S100β及JAK2/STAT3通路相关基因(JAK2、STAT3、p-STAT3)表达情况。结果:3组治疗前疼痛视觉模拟量表(VAS)评分、CD3^+、CD4^+、CD8^+、CD4^+/CD8^+、IL-2、IL-6、IL-10、TNF-α、NPY、SP、NSE、S100β及JAK2、STAT3、p-STAT3表达比较差异无统计学意义(P>0.05);3组治疗后CD3^+、CD4^+、CD4^+/CD8^+、IL-2均较治疗前明显升高,VAS评分、CD8^+、IL-6、IL-10、TNF-α、NPY、SP、NSE、S100β及JAK2、STAT3、p-STAT3表达均较治疗前明显降低,差异有统计学意义(P<0.05),且联合治疗组改善程度明显优于泼尼松组、普瑞巴林组,差异有统计学意义(P<0.05)。结论:普瑞巴林联合泼尼松治疗带状疱疹后遗神经痛,能够改善患者疼痛症状和细胞免疫功能。

Objective: To investigate the effect of pregabalin combined with prednisone on immune function and inflammatory cytokines in patients with postherpetic neuralgia, and to explore the mechanism involved. Methods: 135 patients with postherpetic neuralgia were randomly divided into prednisone group(prednisone alone), pregabalin group(pregabalin alone) and combined therapy group(pregabalin combined with prednisone treatment), 45 patients in each group. T cell subsets(CD^3+, CD^4+, CD^8+ and CD^4+/CD^8+), inflammatory cytokines(IL-2, IL-6, IL-10 and TNF-α), pain substances(NPY and SP), NSE, S100β and the expressions of JAK2/STAT3 signaling pathway related genes of the three groups were compared and analyzed. Results: Before treating, there was no significant difference in VAS scores, CD^3+, CD^4+, CD^8+, CD^4+/CD^8+, IL-2, IL-6, IL-10, TNF-α, NPY, SP, NSE, S100β and the expression of JAK2, STAT3, p-STAT3 between the three groups(P>0.05);CD^3+, CD^4+, CD^4+/CD^8+, and IL-2 were significantly increased in the three groups after treatment, VAS score, CD^8+, IL-6, IL-10, TNF-α, NPY, SP, NSE, S100β and JAK2, and the expressions of STAT3 and p-STAT3 were significantly lower than those before treatment, and the difference was statistically significant(P<0.05). The improvement degree of the combined therapy group was significantly better than that of the prednisone group and the pregabalin group. The difference was statistically significant(P<0.05). Conclusion: Pregabalin combined with prednisone in the treatment of postherpetic neuralgia can improve pain and cellular immune function.