中药治疗化疗致白细胞减少症的研究进展

Research progress on Chinese materia medica in treatment of chemotherapy-induced leukopenia

白细胞减少症是肿瘤患者化疗的严重毒副作用之一,影响肿瘤患者的治疗进程和预后与转归。临床上主要靠粒细胞集落刺激因子等集落刺激因子类药物治疗该并发症,该类药物虽然能提升白细胞的数量,但对白细胞功能的提升相对不足,且价格昂贵、伴随一定毒副作用,因此临床应用存在一定的局限性。中医药在防治化疗毒副作用、减轻白细胞减少的症状方面具有独特优势和多向性作用特征。通过文献资料的检索分析,综述了治疗肿瘤化疗后白细胞减少症的中医药研究进展,为临床上中医药治疗白细胞减少症提供参考。

Leukopenia is one of the serious side effects of chemotherapy in cancer therapy, which affects the treatment progress, prognosis, and outcome of cancer patients. Clinically, it mainly relies on colony-stimulating factor drugs such as granulocyte colony-stimulating factor(G-CSF). However, with the increase of white blood cells number, its function is relatively insufficient. What’s more, the price of G-CSF is high, which is accompanied by certain toxic as well as side effects. So the clinical application is limited. Traditional Chinese medicine has unique advantages and multi-directional effects in preventing and treating chemotherapy side effects and reducing the symptoms of leukopenia. This article reviews the progress of traditional Chinese medicine in the treatment of leukopenia after chemotherapy by literature retrieval, and provides a reference for the treatment of leukopenia with traditional Chinese medicine in clinic.