循环肿瘤DNA在胃癌诊断中的临床应用

Clinical Applications of Circulating Tumor DNA in Diagnosis of Gastric Cancer

胃癌是全球第5大高发癌症,亦是第3大癌症死亡原因。胃癌的常规治疗包括手术切除和辅助治疗等。超过50%的患者早期症状不典型,诊断时已处于晚期。研究者不断探索更敏感的检测手段来检测胃癌的发生、发展,除通过蛋白质组学技术研究血清肿瘤标志物外,目前还引入了循环肿瘤DNA的概念。本文就循环肿瘤DNA在胃癌诊断中的临床应用作一综述。

Gastric cancer is the fifth most common type of cancer in the world and the third leading cause of cancer death. Conventional treatment for gastric cancer includes surgical resection and adjuvant therapy. More than 50% of patients are reaching the advanced stage when diagnosed, because they do not have typical symptoms at early stage. Researchers continue to investigate more sensitive methods for detecting the occurrence and development of gastric cancer. In addition to new serum tumor biomarkers through proteomics, new concept such as circulating tumor DNA (ctDNA) has also been introduced. This article reviewed the clinical application of ctDNA in diagnosis of gastric cancer.