重楼皂苷Ⅰ抗消化系统恶性肿瘤的作用及其机制研究进展

Advances in Research on Role and Mechanism of Polyphylla Saponin Ⅰ in Digestive System Tumors

重楼皂苷Ⅰ是重楼最主要的有效成分,现代药学研究表明,重楼皂苷Ⅰ可有效抑制消化系统恶性肿瘤的发生、发展,其主要机制可能是抑制肿瘤细胞增殖、促进肿瘤细胞凋亡、抑制肿瘤新生血管形成、抑制肿瘤细胞迁移、调节肿瘤细胞的免疫功能、调节肿瘤细胞对化疗药物的抵抗等。本文就此作一综述。

Polyphylla saponin Ⅰ is the major effective ingredient of polyphylla. Pharmacology research showed that polyphylla saponin Ⅰ could effectively inhibit the occurrence and development of malignant tumor of digestive system via inhibiting tumor cell proliferation, promoting tumor cell apoptosis, inhibiting tumor neovascularization, inhibiting tumor cell migration, regulating tumor cell immune function, regulating tumor cell resistance to chemotherapeutic drugs. This article reviewed the role and mechanism of polyphylla saponin Ⅰ in digestive system tumors.