血清胃功能四项指标检测在胃部疾病中的应用价值

Application value of serum gastric function tests in gastric diseases

目的分析胃功能四项指标〔即胃蛋白酶原Ⅰ(PGⅠ)、胃蛋白酶原Ⅱ(PGⅡ)、胃泌素17(G-17)和PGⅠ/PGⅡ比值(PGR)〕、幽门螺杆菌(Hp)免疫球蛋白G(IgG)抗体在胃部疾病中的应用。方法选择曲靖市第二人民医院门诊就诊的122例胃部不适患者,根据胃镜检查结果分为慢性浅表性胃炎组(77例)、慢性浅表性胃炎伴糜烂组(24例)、慢性浅表性胃炎伴萎缩组(21例),另选50例健康人群为健康对照组。采用酶联免疫吸附试验(ELISA)检测所有受检者的血清PGⅠ、PGⅡ、G-17,并计算PGR值,对比各组受检者的血清胃功能四项水平,分析其在健康人群以及不同类型胃部疾病患者中的差异。结果与健康对照组比较,慢性浅表性胃炎组及其伴糜烂组的PGⅡ均明显降低(μg/L:5.22±4.80、3.65±2.44比8.02±4.35,均P<0.05),PGR均明显升高(24.93±214.55,29.98±19.29比13.82±4.23,均P<0.05),而PGⅠ和G-17差异均无统计学意义(均P>0.05)。慢性浅表性胃炎伴糜烂组PGR明显高于伴萎缩组(29.98±19.29比16.14±5.33,P<0.05),PGⅡ明显低于伴萎缩组(μg/L:3.65±2.44比5.78±2.26,P<0.05)。健康对照组、慢性浅表性胃炎组、慢性浅表性胃炎伴糜烂组和慢性浅表性胃炎伴萎缩组的血清Hp IgG抗体阳性率分别为12.00%、37.66%、29.17%和42.86%,各组间比较差异有统计学意义(P=0.009)。结论血清胃功能检测方便快捷,能被广大患者所接受,单一指标在评价胃部疾病时存在缺陷,四项指标联合检测能更全面地反映胃黏膜的功能和状态。

Objective To analyze the application values of Gastric function four indexes,including pepsinogenⅠ(PGⅠ),pepsinogenⅡ(PGⅡ),PGⅠ/PGⅡ(PGR)and stomach gastrin-releasing 17(G-17)and helicobacter pylori IgG antibodies in the evaluation of stomach diseases.Methods One hundred and twentytwo patients with stomach discomfort who were selected from the Outpatient Department of Qujing Second People's Hospital,and according to gastroscopic examination results,they were divided into chronic superficial gastritis group(77 cases),chronic superficial gastritis with erosion group(24 cases)and chronic superficial gastritis with atrophy(21 cases)group;the other 50 healthy people were assigned in a control group.The serum PG Ⅰ,PG Ⅱ,and G-17 of all the subjects were measured by enzyme-linked immunosorbent assay(ELISA),and PGR values were calculated.The levels of four serum gastric function indexes were compared between the groups,and the differences were statistically analyzed in healthy people and patients with different types of gastric diseases.Results Compared with healthy control group,PG Ⅱ was significantly decreased in chronic superficial gastritis group and chronic superficial gastritis with erosion group(μg/L:5.22±4.80,3.65±2.44 vs.8.02±4.35,all P<0.05),PGR was obviously increased(24.93±14.55,29.98±19.29 vs.13.82±4.23,all P<0.05),while there were no statistical significant differences in PG Ⅰ and G-17(all P>0.05).Compared with the chronic superficial gastritis with atrophy group,the PGR of the chronic superficial gastritis with erosion group were significantly increased(29.98±19.29 vs.16.14±5.33,P<0.05),while PGⅡin chronic superficial gastritis with erosion group was markedly lower(μg/L:3.65±2.44 vs.5.78±2.26,P<0.05).The positive rates of serum Hp IgG antibodies in healthy control group,chronic superficial gastritis group,chronic superficial gastritis with erosion group and chronic superficial gastritis with atrophy group were 12.00%,37.66%,29.17%,42.86%,and the differences between each two of the four groups were statistically significant(P=0.009).Conclusions The serum gastric function tests are convenient and fast,and can be accepted by the majority of patients.Using single index to evaluate the state of gastric disease has defects,and the four combined tests can more comprehensively reflect the function and state of gastric mucosa.