药物性角膜病变诊治的临床观察

目的研究药物性角膜病变的临床特征及诊治疗效.方法回顾分析2016年1月至2018年3月在十堰市太和医院眼科诊断为药物性角膜病变并接受治疗患者病例资料.结果共有10例药物性角膜病变患者纳入本研究.4例为白内障术后患者,6例为其他眼病患者,均频点抗炎、抗病毒药或糖皮质激素等滴眼液.治疗上采用停用原药物,加用人工泪液、生长因子,包扎,激素眼水,绷带角膜接触镜及羊膜移植等方法.经过对症治疗,全部治愈,治愈时间为4d^2个月,5例患者病情轻预后较好,5例病情重者角膜瘢痕愈合,影响视力.结论眼科医生对药物性角膜病变的认识尚不充分,药物性角膜病变临床表现多样化,及时发现并对症治疗,预后较好,否则将影响视力预后.

Objective To investigate the clinical characteristics,diagnosis,and treatments of drug—induced keratopathy.Methods The case-series patients with drug-induced keratopathy,who received treatments in Ophthalmology Department of Taihe Hospital in Shiyan were analyzed retrospectively from 2016.1 to 2018.3.Results There were 10 patients with drug-induced keratopathy included in the study.4 cases underwent cataract surgery and 6 cases with ocular diseases were frequcndy administered with antibiotics,antiviral or corticosteroids.The treatments included withdrawing the drug that induced the keratopathy,adding artificial tears and growth factors,bandage,corticosteroids eye drops,wearing bandage comeal contact lens and amniotic membrane transplantation.All patients were cured after treatments and the cure time ranged from 4 days to 2 months.5 mild patients recovered well,but 5 serious cases recovered with comeal scar impacting vision obviously.Conclusion The clinical ophthalmologists do not get enough insight into drug-induced keratopathy.The clinical manifestations of drug-induced keratopathy vary widely,and the prognosis is better if detected and treated early,otherwise it will affect the vision.