生命早期一千天与健康关系研究进展

Research progress in association of first thousand days in life and human health

生命早期不仅是人体生理、免疫系统、代谢及结构发育的时期,而且还可以改变机体长期的细胞功能,从而与人类近远期的健康及疾病产生联系。因此,生命早期,尤其是最初的一千天,在人类健康中发挥重要作用,也被认为是预防生命后期疾病发生的关键时期,备受研究关注,然而这种影响机制尚不明确。现对生命早期一千天的重要意义进行阐述,并从不同角度对生命早期一千天与健康的关系进行综述。

Early days in life can not only affect people′s physiology,immune system,metabolism and structural development,but also can alter body cell functions in long term,which in turn has an impact on human′s health and diseases both in short and long term.Thus,early days,especially the first thousand days in life play an important role in human health and is thought to be a key period for preventing certain diseases later in life,which is under heated investigation.However,the mechanisms for this impact are not clear.This review emphasizes the importance of the first thousand days in human life and elucidates its association with human health from multiple aspects.