复方乌金汤辅助治疗对急性肝损伤患者血清NO、NOS水平的影响观察

Effect of Compound Wujin Decoction Adjuvant Therapy on Serum NO and NOS Levels for Patients with Acute Liver Injury

目的:观察复方乌金汤辅助治疗对急性肝损伤患者血清一氧化氮(NO)、一氧化氮合成酶(NOS)水平的影响。方法:回顾性分析2016年1月~2018年6月间收治的84例急性肝损伤患者临床资料,根据患者治疗方案分为观察组(n=40)和对照组(n=44)。对照组予以常规治疗方案,观察组在此基础上增加复方乌金汤。比较两组临床疗效,评估治疗前、治疗1月后症状体征积分,肝功能[谷氨酸转氨酶(ALT)、天门冬氨酸氨基转移酶(AST)、谷氨酰转肽酶(GGT)、碱性磷酸酶(ALP)]、氧化应激反应(NO、NOS)。结果:①治疗1个月后,观察组治疗总有效率高于对照组(P<0.05);②治疗1个月后,两组症状体征积分均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05);③治疗1个月后,两组ALT、AST、GGT、ALP水平均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05);④治疗1个月后,两组NO、NOS水平均低于治疗前(P<0.05),观察组降幅大于对照组(P<0.05)。结论:复方乌金汤辅助治疗急性肝损伤有利于降低患者血清NO、NOS水平,改善其肝功能和临床疗效,具有一定临床应用价值。

Objective:To explore the effect of Compound Wujin Decoction adjuvant therapy on serum levels of nitric oxide(NO) and nitric oxide synthase(NOS) for patients with acute liver injury. Methods:The clinical data of 84 patients with acute liver injury who were admitted between January 2016 and June 2018 were retrospectively analyzed. The patients were divided into observation group(n=40) and controlled group(n=44) according to the treatment regimens. The controlled group was given routine treatment regimen, and the observation group was added with Compound Wujin Decoction on this basis. The clinical efficacy of the two groups was compared, and the symptoms and signs scores, liver function [alanine transaminase(ALT), aspartate aminotransferase(AST), glutamyl transpeptidase(GGT), alkaline phosphatase(ALP)] and oxidative stress response(NO, NOS) were evaluated before treatment and after 1 month of treatment. Results:After 1 month of treatment, the total effective rate of treatment in the observation group was higher than that in the controlled group(P<0.05). After 1 month of treatment, the scores of symptoms and signs in the two groups were lower than those before treatment(P<0.05), and the decreases in the observation group were greater than those in the controlled group(P<0.05). After 1 month of treatment, the levels of ALT, AST, GGT and ALP in the two groups were lower than those before treatment(P<0.05), and the decreases in the observation group were greater than those in the controlled group(P<0.05). After 1 month of treatment, the levels of NO and NOS in the two groups were lower than those before treatment(P<0.05), and the decreases in the observation group were greater than those in the controlled group(P<0.05). Conclusions:Compound Wujin Decoction adjuvant therapy for acute liver injury is beneficial to reduce serum NO and NOS levels and improve liver function and clinical efficacy, and it has certain clinical application value.