基于总量统计矩理论的中药质量标志物研究策略

Research strategy of quality markers of Chinese materia medica based on total quantum statistical moment theory

中药质量的控制是保障中医临床用药安全、有效的基础。中药加工全过程对最终质量影响巨大,中药质量标志物的研究及确定对中药物质基础研究、中药材鉴别、中药炮制、中药制剂加工等中药生产全过程具有重要意义。总量统计矩可以全面反映中药指纹图谱信息,具有加和性、偶联性和强大的抗干扰性,可用于中药制药全过程的定性与定量分析,还可用于探讨中药复方配伍规律及其体内代谢过程研究,能够实现对中药及其复方质量的全面反映。通过系统分析中药质量标志物研究进展及总量统计矩法的原理及应用,尝试利用总量统计矩法为中药质量标志物的研究及确定提供思路。

The quality control of Chinese materia medica(CMM) is the basis for ensuring the safety and effectiveness of clinical medication of traditional Chinese medicine. The whole process of Chinese medicine processing has a great impact on the final quality. The research and determination of the Q-marker of CMM are of great significance to the substance basis research on CMM, the identification of Chinese medicinal materials, the processing of CMM, and the processing of CMM pharmaceutics. The total quantum statistical moment(TQSM) can fully reflect the chromatographic fingerprints information of CMM, with additive, coupling and strong anti-interference. It can be used for qualitative and quantitative analysis of the whole process of CMM, and can also be used to explore the pharmaceutic rule of Chinese medicine compound and its pharmacokinetic process, which can achieve a comprehensive reflection of the quality of CMM and its compound. Through systematic analysis of the research progress of Chinese medicine Q-marker and the principle and application of TQSM, this paper attempts to provide ideas for the research and determination of Chinese medicine quality markers based on TQSM.