瓜蒌化学成分和药理作用研究进展及质量标志物预测分析

Research progress on chemical composition and pharmacological effects of Trichosanthis Fructus and predictive analysis on quality marker

瓜蒌TrichosanthisFructus是我国传统常用中药材,分布范围广,资源丰富。随着对瓜蒌各方面研究逐渐深入,其有效成分及应用研究受到广泛的关注,具有较大的应用前景。在对其化学成分及主要的药理作用进行总结的基础上,根据质量标志物定义,从化学成分的生源途径和成分特异性及其与中药有效性、成分可测性的相关性等几方面对瓜蒌质量标志物进行预测分析,为瓜蒌质量评价研究提供科学依据。

Trichosanthis Fructus is a traditional Chinese herbal medicine,which has wide distribution and rich medicine source.With the in-depth study of Trichosanthis Fructus,its effective ingredients and application research has attracted much attention,and has great application prospects.Based on a summary of its chemical composition and main pharmacological effects,according to the definition of quality marker(Q-marker),the quality marker components of Trichosanthis Fructus were predicted from the aspects of the biosynthetic approach and component specificity of chemical components and their correlation with the effectiveness of Chinese medicines and the measurability of components,which provides a scientific basis for quality evaluation of Trichosanthis Fructus.