桑菊饮治疗喉源性咳嗽Meta分析

Meta-analysis of Sangju Decoction in Treatment of Laryngeal Cough

【目的】评价桑菊饮为主方治疗喉源性咳嗽的临床疗效和安全性。【方法】电子计算机检索中国知网(CNKI)、维普(VIP)、万方、PubMed等数据库中桑菊饮加减(试验组)对比常规西药(对照组)治疗喉源性咳嗽的随机对照试验,评估纳入文献的偏倚风险,采用RevMan 5.2软件进行Meta分析。【结果】共纳入10篇符合标准的文献,涉及1202例患者。Meta分析结果表明,与对照组比较,桑菊饮为主方治疗喉源性咳嗽疗效显著(OR=4.14,95%CI[3.01,5.69],P<0.01)。有2项研究中对照组存在不同程度的不良反应,试验组则无相关不良反应报道。【结论】以桑菊饮为主方治疗喉源性咳嗽疗效显著,不良反应少。但由于纳入研究样本量较少,研究质量偏低,引用本研究结论时需谨慎对待;桑菊饮治疗喉源性咳嗽的疗效及安全性仍需高质量、大样本的随机对照试验进一步验证。

Objective To evaluate the clinical efficacy and safety of Sangju Decoction in the treatment of laryngeal cough.Methods Computer retrieval was carried out in the databases of CNKI,VIP,Wanfang and PubMed.The randomized clinical trials(RCTs)of Sangju Decoction(trial group)vs conventional western medicine(control group)in the treatment of laryngeal cough were collected.The risk of bias of the included trials was evaluated and Meta-analysis was performed with RevMan 5.2 software.Results A total of 10 RCTs involving 1202 cases were included in the study.The Meta-analysis results showed that the clinical efficacy of Sangju Decoction was superior to that of the control group(OR=4.14,95%CI[3.01,5.69],P<0.01)in the treatment of laryngeal cough.Adverse reactions with different degrees were reported in the control group of 2 trials,while no adverse reactions were reported in the trial group.Conclusion Sangju Decoction has obvious curative effect and is safe in treating laryngeal cough.However,due to the small sample size and low quality of the included trials,the conclusion should be interpreted cautiously,and still needs more high-quality and large-sample-size trials to verify.