妊娠女性血淋巴细胞计数与单核细胞计数比例和早产相关性回顾研究

A retrospective study on the relationship between LMR and preterm delivery in pregnant women

目的探讨妊娠早期及中晚期孕妇血清的炎症标志物--淋巴细胞计数与单核细胞计数比例(LMR)和早产的相关性。方法于2016年8月至2017年11月在重庆医科大学附属第二医院建立一支正常妊娠研究队列,以妊娠终止时是否满37周作为分组依据,≥28周且<37周为研究组,共100例;≥37周对照组,共116例。回顾两组在产检建档时(妊娠11~13周),以及妊娠满28周后第1次产检时(妊娠28周至30周)的全血细胞结果。结果相较于足月产孕妇,早产孕妇在尚未出现临床症状前,LMR水平已明显增高(妊娠早期4.90±1.40 vs. 4.31±1.30,P<0.01;妊娠中晚期3.54±0.93 vs. 2.95±0.64,P<0.01),且LMR水平和妊娠终止时的孕周呈负相关(r=-0.350,P<0.01)。结论妊娠期LMR水平与是否发生早产具有相关性,有必要进一步研究和探讨。

Objective To study a potential relationship between preterm labor and lymphocyte to monocyte ratio(LMR).Methods This retrospective cohort study was conducted in Second Affiliated Hospital of Chongqing Medical University from August 2016 to November 2017. Totally 100 pregnant women who delivered between 28 th to 37 th gestational week were included as the study group,and 116 pregnant women who delivered after 37 th gestational week were as the control group. The data of routine blood test from 11 th to 13 th gestational week and 28 th to 30 th gestational week were observed and compared.Results The LMR value of preterm women was significantly higher than that of those who delivered at term(early pregnancy 4.90±1.40 vs. 4.31±1.30,P<0.01;middle and advanced stage of pregnancy 3.54±0.93 vs. 2.95±0.64,P<0.01). A negative correlation was observed between the level of LMR and the gestational weeks of termination of pregnancy(r=-0.350,P<0.01).Conclusion The value of LMR in pregnancy is associated with the occurrence of preterm labor. Therefore,it is necessary to make further study.