四降三萜solanoeclepin A的合成研究进展

Recent Progresses in the Synthesis of Solanoeclepin A

Solanoeclepin A是由Mulder等从茄科植物马铃薯根部分离得到,是一种具有非常独特骨架结构的四降三萜类天然产物.研究表明,其对造成土豆大量减产的土豆包囊线虫(PCN,Globodera rostochiensis and G.pallida)的孵化过程具有极强的诱导活性(0.3 g/ha土地).结合Corey教授关于glycinoeclepin的仿生合成工作,提出了solanoeclepin A可能的生源合成途径,综述了目前已报道的solanoeclepin A的全合成及片段合成策略.

Solanoeclepin A,first isolated from potato roots(Solanaceae Juss.)by Mulder et al.,is an highly active hatching stimulant(0.3 g per hectare)of potato cyst nematode(PCN,Globodera rostochiensis and G.pallida)which causes severe damage to potato crops.Its complex chemical structure belongs to a rearranged tetranortriterpene and possesses extremely unique skeleton.Based on the known general biosynthesis of tetranortriterpenoids and Prof.Corey’s biomimetic synthesis of glycinoeclepin,a plausible biosynthetic pathway of solanoeclepin A is proposed.A schematic review on the synthetic studies towards solanoeclepin A is provided.