无过渡金属参与的三芳基膦化合物合成新方法研究

A Novel Method for the Synthesis Triarylphosphines under Transition-Metal-Free Conditions

三芳基膦化合物在医药合成、过渡金属催化等方面扮演十分重要的角色.报道了碱促进的芳基卤代物与烷基取代的二芳基膦的C(sp2)—P键偶联新方法合成三芳基膦.该方法具有无过渡金属催化剂参与、反应底物来源广泛、后处理简洁等优点.

Triarylphosphines play an important role in pharmaceutical synthesis and transition-meal-catalyzed reactions.In this paper,a novel method for the synthesis of triarylphosphines via base-promoted C(sp2)—P cross-coupling reactions of alkyldiphenylphosphines with aryl halides is described.The transition-metal-free reaction condition,readily available starting materials and experimental simplicity are the features of the novel method.