Plac1在肝细胞癌组织中的表达及临床意义

Expression and clinical significance of Plac1 in hepatocellular carcinoma

目的:探讨胎盘特异基因1(placenta-specific 1,Plac1)在肝细胞癌(hepatocellular carcinoma,HCC)组织中的表达及其临床意义。方法:采用免疫组织化学法检测97例HCC组织及10例非肝癌的正常肝组织中Plac1的表达,并分析其与HCC临床病理特征及与患者预后的关系。结果:97例肝癌组织中,Plac1阳性表达51例,阳性表达率为52.6%,而在10例非肝癌的正常肝组织中不表达。Plac1蛋白的表达水平与患者的年龄、性别、血清AFP水平、肿瘤大小、是否有肝硬化及HBsAg阳性与否无关(P>0.05),但与癌栓的形成及肿瘤转移相关(P<0.05)。Plac1阳性表达组HCC患者的术后生存时间明显低于Plac1阴性表达组HCC患者(P<0.05),提示Plac1的表达可能与HCC患者的预后有关。结论:Plac1表达升高可能与HCC的发生发展密切相关。

Objective:To investigate the expression and clinical significance of placenta-specific 1(Plac1) in hepatocellular carcinoma(HCC).Methods:The protein expression of Plac1 was detected by immunohistochemistry in paraffin sections obtained from 97 patients with HCC,and 10 cases of non-cancerous liver tissues were used as controls.The correlation between the Plac1 expression and the clinical significance was evaluated.Results:Plac1 expression was highly up-regulated in 52.6%(51/97) HCC tissues,but non-cancerous liver tissues exhibited negative Plac1 staining.The expression of Plac1 in HCC had no correlation with gender,age,serum AFP,HBsAg,tumor size or cirrhosis(P>0.05),but significantly with tumor thrombus and metastasis(P<0.05).The overall survival of HCC patients in the Plac1 positive group was significantly poorer than that of patients in the Plac1 negative group(P<0.05),suggesting that Plac1 was associated with a poor prognosis in HCC patients.Conclusion:The up-regulated expression of Plac1 may be involved in the HCC occurrence and development.