脊髓小脑共济失调2型小脑外症状及非运动症状研究进展

Research progress of non-motor and extracerebellar symptoms in spinocerebellar ataxia type 2

脊髓小脑共济失调2型(spinocerebellar ataxia type 2,SCA2)是一种常染色体显性变性疾病,主要临床表现是进行性小脑综合征,但在临床上可以观察到广泛的小脑外症状和非运动症状。通过了解SCA2中的非运动和小脑外症状的特征,提高我们对该病的认识及诊疗水平。

Spinocerebellar ataxia type 2(SCA2)is an autosomal dominant degenerative disease.The main clinical manifestation of SCA2 is progressive cerebellar syndrome,but a wide range of extracerebellar and non-motor symptoms can be observed clinically.The non-motor symptoms and extra-cerebellar signs in SCA2 patients are reviewed to provide a better understanding in cognition,diagnosis and treatment of the disease.