丹参多酚酸盐联合前列地尔治疗糖尿病肾病的效果

Effect of Salvianolate Combined with Alprostadil on the Diabetic Nephropathy

目的:探讨丹参多酚酸盐联合前列地尔治疗糖尿病肾病的效果。方法:选取2015年11月~2018年11月我院收治的糖尿病肾病患者114例,采用随机数字表法将患者分为两组。对照组在常规治疗的基础上给予前列地尔注射液,观察组在对照组的基础上给予丹参多酚酸盐注射液。比较两组患者的临床治疗效果、治疗前后肾功能、血糖水平、血清可溶性细胞间粘附分子1(s ICAM-1)及内皮素(ET-1)水平的变化及不良反应的发生情况。结果:治疗后,观察组治疗的总有效率为91.23%,显著高于对照组(73.68%,P<0.05)。两组患者治疗后的血肌酐(Scr)、尿素氮(BUN)、β2-微球蛋白(β2-MG)、尿蛋白排泄率(UAER)、血清s ICAM-1及ET-1水平均较治疗前显著下降(P<0.05),且观察组以上指标均显著低于对照组(P<0.05)。两组患者治疗前后及两组间的糖化血红蛋白(HbALc)及空腹血糖(FPG)水平比较均无统计学差异(P>0.05)。两组患者均未发生严重不良反应,轻微不良反应均经对症处理后好转,且不影响治疗。结论:丹参多酚酸盐联合前列地尔可显著改善糖尿病肾病患者的肾功能、提高临床治疗效果,且不影响血糖水平,可能与其显著降低患者血清s ICAM-1及ET-1水平有关。

Objective: To investigate the clinical efficacy of salvianolate combined with alprostadil in the treatment of diabetic nephropathy. Methods: 114 cases of patients with diabetic nephropathy admitted to our hospital from November 2015 to November 2018 were selected. The patients were divided into two groups by random number table method. The control group was given alprostadil injection on the basis of conventional treatment, and the observation group was given salvianolate injection on the basis of the control group.The clinical treatment effect, changes of renal function, blood glucose level, serum s ICAM-1 and ET-1 before and after treatment, and occurrence of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate in the observation group was 91.23%, which was significantly higher than that in the control group(73.68%, P<0.05). After treatment, the levels of Scr,BUN, β2-MG, UAER, serum s ICAM-1 and ET-1 of both groups were significantly lower than those before treatment, and the above indexes in the observation group were significantly lower than those in the control group(P<0.05). There was no significant difference in the HbALc and FPG levels between the two groups before and after treatment(P>0.05). No serious adverse reactions occurred in the two groups, and mild adverse reactions improved after symptomatic treatment without affecting treatment. Conclusion: Salvianolate combined with alprostadil can significantly improve the renal function of patients with diabetic nephropathy without affecting the blood glucose level, which may be related to the significant improvement of serum s ICAM-1 and ET-1 levels.