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白介素-6受体拮抗剂在多关节型幼年特发性关节炎的应用进展 被引量:6

Progress in the application of IL-6 receptor antagonist in polyarticular juvenile idiopathic arthritis
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摘要 幼年特发性关节炎(juvenile idiopathic arthritis,JIA)是指16岁以下儿童不明原因持续6周以上的慢性关节炎,是一类异质性疾病,发病率为16/100000~150/100000[1]。根据2001年国际风湿病联盟(International League of Associations for Rheumatology,ILAR)分类,JIA分7型,常见类型包括少关节型、多关节型以及全身型等。
作者 凌加云 胡秀芬 LING Jia-yun;HU Xiu-fen
出处 《中国实用儿科杂志》 CSCD 北大核心 2019年第10期872-876,共5页 Chinese Journal of Practical Pediatrics
关键词 多关节型幼年特发性关节炎 治疗 白介素-6 托珠单抗 polyarticular juvenile idiopathic arthritis treatment interleukin-6 tocilizumab
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  • 2Otten MH, Prince FH, Twilt M, et al. Tumor necrosis factor-blocking agents for children with enthesitis-related arthritis-data from the dutch arthritis and biologicals in children register, 1999-2010[J]. J Rheumatol,2011, 38(10):2258-2263.
  • 3Petty RE, Southwood TR, Manners P, et al. International league of associations for rheumatology classification of juvenile idiopathic arthritis:second revision,Edmonton[J]. J Rheumatol, 2004, 31(2):390-392.
  • 4Shenoi S, Wallace CA.Tumor necrosis factor inhibitors in the management of juvenile idiopathic arthritis:an evidence.based review[J].Pediatr Drugs,2010,12(6):367-377.
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  • 6Sfikakis PP. The first decade of biologic TNF antagonists in clinical practice:lessons learned, unresolved issues and future directions[J].Curr Dir Autoimmun,2010, 11(1):180-210.
  • 7Alexeeva EI, Valieva SI, Bzarova TM, et al. Efficacy and safety of repeat courses of rituximab treatment in patients with severe refractory juvenile idiopathic arthritis[J]. Clin Rheumatol, 2011, 30(9):1163-72.
  • 8Levalampi T, Honkanen V, Lahdenne P, et al.Effects of infliximab on cytokines,myeloperoxidase,and soluble adhesion molecules in patients with juvenile idiopathic arthritis[J].Scand J Rheumatol, 2007, 36(3):189-193.
  • 9Ruperto N, LoveU DJ,Cuttica R, et al.Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticulareoulse juvenile rheumatoid arthritis:findings from an open-label treatment extension[J].Ann Rheum Dis,2010,69(4):718-722.
  • 10Hashkes PJ, Uziel Y, Laxer RM.The safety profile of biologic therapies for juvenile idiopathic arthritis[J].Nat Rev Rheumatol, 2010, 6(10):561-571.

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