Sclerotiorin的胺类衍生物的潜在抗病毒活性及其初步构效关系研究（英文）

Potential antiviral sclerotiorin amine derivatives and their preliminary structure-activity relationship

目的 为了评价天然产物(+)-sclerotiorin及其半合成衍生物的抗病毒活性。方法 通过CPE法评价(+)-sclerotiorin(1)及其半合成衍生物(2~31)对RSV、EV71、HSV-1、H1N1和Cox-B3的抗病毒活性。结果化合物3和11显示出对EV71的抗病毒活性,并且具有非常高的选择性指数值(SI值分别为37.8和38.0)。结论 化合物3和11是潜在的抗病毒先导化合物。

Objective To evaluate antiviral activity of the natural compound,(+)-sclerotiorin and its semisynthetic derivatives.Methods(+)-Sclerotiorin(1)and its semisynthetic derivatives(2?31)were evaluated for their antiviral activities against RSV,EV71,HSV-1,H1N1,and Cox-B3 by the CPE inhibition assay.Results Compounds 3 and 11 showed potent and selective antiviral activity against EV71,and had very high selectivity index values(SI 37.8 and 38.0,respectively).Conclusion Compounds 3 and 11 are potent antiviral candidates.