盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者龈沟液TNF-α、IL-1β、IL-8水平及生活质量的影响

Effects of Minocycline Hydrochloride Ointment Combined with Ibuprofen on the Levels of TNF-α, IL-1β and IL-8 in Gingival Crevicular Fluid and Quality of Life in Patients with Chronic Periodontitis

目的:探讨盐酸米诺环素软膏联合布洛芬对慢性牙周炎患者龈沟液肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)、白细胞介素-8(IL-8)水平及生活质量的影响。方法:选取成都医学院第一附属医院于2016年3月至2018年3月期间收治的84例慢性牙周炎患者,按照数表法随机分为观察组(n=42)和对照组(n=42)。对照组患者予以盐酸米诺环素软膏治疗,观察组患者则在对照组的基础上联合布洛芬治疗,比较两组临床治疗总有效率,比较治疗前、后龈沟液TNF-α、IL-1β、IL-8水平,治疗前后菌斑指数(PLI)、牙龈指数(GI)水平,采用健康检查简表(SF-36)评价两组患者生活质量。结果:观察组临床治疗总有效率明显高于对照组(P<0.05)。治疗后观察组患者龈沟液TNF-α、IL-1β、IL-8水平均明显低于对照组(P<0.05)。治疗后观察组患者PLI、GI水平均明显低于对照组(P<0.05)。治疗后观察组SF-36量表各维度评分均显著高于对照组(P<0.05)。结论:盐酸米诺环素软膏联合布洛芬治疗慢性牙周炎的疗效确切,且有效降低患者龈沟液TNF-α、IL-1β、IL-8水平,有利于牙周组织的重建和恢复,提高患者生活质量。

Objective: To investigate the effects of minocycline hydrochloride ointment combined with ibuprofen on the levels of tumor necrosis factor-alpha(TNF-α), interleukin-1β(IL-1β), interleukin-8(IL-8) in gingival crevicular fluid and quality of life in patients with chronic periodontitis. Methods: 84 patients with chronic periodontitis admitted to First Affiliated Hospital of Chengdu Medical College from March 2016 to March 2018 were randomly divided into observation group(n=42) and control group(n=42) according to the number table method. Patients in the control group were treated with minocycline hydrochloride ointment, while patients in the observation group were treated with ibuprofen on the basis of the control group. The total effective rate of clinical treatment was compared between the two groups. The levels of TNF-α, IL-1β and IL-8 in gingival crevicular fluid, plaque index(PLI) and gingival index(GI) before and after treatment were compared, and the quality of life of the two groups was evaluated by health checklist(SF-36).Results: The total effective rate of the observation group was significantly higher than that of the control group(P<0.05). After treatment,the levels of TNF-α, IL-1β and IL-8 in gingival crevicular fluid in the observation group were significantly lower than those in the control group(P<0.05). After treatment, PLI and GI levels in the observation group were significantly lower than those in the control group(P<0.05). After treatment, the SF-36 scale scores in the observation group were significantly higher than those in the control group(P<0.05).Conclusion: Minocycline hydrochloride ointment combined with ibuprofen is effective in the treatment of chronic periodontitis, and can effectively reduce the levels of TNF-α, IL-1β and IL-8 in gingival crevicular fluid, which is conducive to the reconstruction and recovery of periodontal tissue and improve the quality of life of patients.