磁压榨技术实现无异物胃空肠吻合的研究

Application of magnetic compression technique in gastrojejunostomy:an experimental study

目的以兔为实验动物探讨磁压榨技术实现胃空肠吻合的可行性。方法按既定手术操作路径对8只兔行磁压榨胃空肠吻合术,X线观察磁体脱出48 h后,随机选取4只兔观察吻合口并切取其组织行苏木精-伊红(HE)和Masson染色;余4只结扎幽门,14 d后行碘海醇造影以观察吻合口通畅性及渗漏情况。结果8只兔均成功实施磁压榨胃空肠吻合术,术后动物存活良好,磁体在8~12 d内自行排出。吻合口愈合良好,周围炎性反应轻微,无渗漏;结扎术后1只兔因吻合口漏而死亡,余兔生存良好,造影显示通畅性能良好。结论磁压榨技术可以实现胃空肠间的吻合,解决幽门梗阻问题,有望发展为一种全新的消化道吻合方式。

Objective To explore the feasibility,safety and effectiveness of Magnetic compression anastomosis(MCA)for gastrojejunostomy in rabbits.Methods 8 rabbits were subjected to gastric-jejunal anastomosis by magnetic compression according to the established surgical operation path.After 48 hours of magnet extubation,4 rabbits were randomly selected to observe the anastomosis and cut its tissues for hematoxylin and eosin(HE)and Masson staining.The remaining 4 rabbits were performed pyloric ligation,and 14 days later,iodohexol angiography was performed to observe the patency and leakage of the anastomosis.Results All the 8 rabbits were successfully treated with gastric-jejunal anastomosis.The animals survived well and the magnets were discharged within 8-12 days.The anastomosis healed well,and the surrounding inflammatory reaction was mild without leakage.After ligation,1 rabbit died due to anastomotic leakage,the rest survived well,and radiography showed good patency.Conclusion MCA can safely realize the anastomosis between stomach and jejunum and solve the problem of pyloric obstruction,which is expected to develop into a new anastomosis of digestive tract.