维生素D营养状况与早产儿相关疾病的研究进展

Advances in correlation between vitamin D nutritional status and diseases in premature infants

早产儿是维生素D缺乏的高危人群,生后补充维生素D已成为共识.但目前早产儿维生素D营养状况不容乐观,维生素D缺乏情况普遍.研究发现维生素D与多种早产儿疾病,如代谢性骨病、呼吸窘迫综合征、支气管肺发育不良、新生儿坏死性小肠结肠炎以及早产儿感染等具有一定相关性.临床医师应认识维生素D对早产儿的重要性,尽早添加维生素D制剂.维生素D补充剂量以维持血清25-羟维生素D在适宜水平为参考.

Premature infants are at high risk of vitamin D deficiency,thereby commonly treated with vitamin D supplementation after birth.However,the nutritional status of vitamin D in premature infants is not optimistic due to the fact of high incidence of vitamin D deficiency.Studies have found that vitamin D is associated with a variety of diseases in premature infants,including metabolic bone disease,respiratory distress syndrome,bronchopulmonary dysplasia,neonatal necrotizing enterocolitis and infection.Clinicians should be aware of the importance of vitamin D for premature infants and prescribe vitamin D supplementation as early as possible with the dose reference of serum 25-hydroxyvitamin D level.