2015—2018年常州地区献血者不规则抗体的检出情况分析

Analysis of the detection of irregular antibodies in blood donors in Changzhou area from 2015 to 2018

目的:研究2015—2018年常州地区不规则抗体的检出情况。方法:对2015—2018常州地区无偿献血者标本进行ABO和Rh(D)血型的检测,采用盐水介质法将ABO正反定型不符、O细胞有反应和Rh(D)初筛阴性的标本送输血研究室确认,输血研究室对送检的标本进行不规则抗体筛查鉴定。结果:244770例献血者血液样本中共检出145例ABO正反定型不符和O细胞有反应标本,经输血研究室确认不规则抗体127例,阳性率0.052%;833例Rh(D)筛查阴性标本,其中Rh(D)阴性标本的不规则抗体数为11例,阳性率0.004%。不规则抗体中以MNS血型系统为主,其中抗-M抗体占抗体总数的47.1%。结论:对无偿献血者进行不规则抗体的筛查鉴定对降低输血不良反应,保障临床用血安全具有重要意义。

Objective:To study the detection of irregular antibodies in Changzhou from 2015 to 2018.Method:The blood samples of ABO and Rh(D)were collected from the unpaid blood donors in Changzhou area from 2015 to 2018.The samples were inconsistent with ABO,O-cell response and Rh(D)negative screening were sent to the blood by saline medium method.The laboratory confirmed that the blood transfusion laboratory performed irregular antibody screening and identification on the specimens sent for examination.Result:A total of 145 ABO positive and negative inconsistencies and O cell-reactive specimens were detected in blood samples of 244770 blood donors.127 cases of irregular antibodies were confirmed by transfusion laboratory,the positive rate was 0.052%;833 cases were negative for Rh(D)screening.In the specimen,the number of irregular antibodies in the Rh(D)negative specimen was 11,and the positive rate was 0.004%.Among the irregular antibodies,the MNS blood group system was the main one,and the anti-M antibody accounted for 47.1%of the total number of antibodies.Conclusion:Screening and identification of irregular antibodies in unpaid blood donors is of great significance in reducing adverse reactions of blood transfusion and ensuring clinical blood safety.