微流控技术在循环肿瘤细胞检测领域的应用

Application of microfluidic technology in detection of circulating tumor cells

癌症早期诊断其目的在于干预,尽可能在前期产开对癌症的治疗,从而减轻病患的痛苦以及经济负担。循环肿瘤细胞(CTCs)是从恶性肿瘤中脱落进入外周血循环系统的肿瘤细胞,当其迁移到远处器官时就会形成癌症转移。CTCs的检测和鉴定对研究、监测和干预癌症转移过程具有重要意义。然而,CTCs在血液中的数量极其稀少,同时血液中环境复杂,这对其筛选和分析带来巨大的技术挑战。目前人们已经开发了各种方法来从富集癌症患者血样中的CTCs。其中微流控技术在CTC检测领域极具优势。

The early diagnosis of cancer is aimed at intervention,as far as possible in the early stage of the treatment of cancer,thereby reducing the suffering and economic burden of the patient.Circulating tumor cells(CTCs)are tumor cells that fall from the malignant tumor into the circulatory system and form cancer metastasis when they migrate to distant organs.The detection and identification of CTCs is important for the study,monitoring and intervention of cancer metastasis processes.However,the amount of CTCs in the blood is extremely rare,and the environment in the blood is complex,which poses a huge technical challenge for its screening and analysis.Various methods have been developed to enrich CTCs from blood samples of cancer patients.Among them,microfluidic technology has great advantages in the field of CTC detection.