MicroRNA在乳腺癌研究中的新进展

New research progress of microRNAs in breast cancer

microRNA(miRNA)是非编码单链RNA分子,其在乳腺癌中的作用已逐渐被发现,并得到了临床的认知和重视。miRNA在乳腺癌中发挥着调控相关靶基因和信号通路的作用,参与乳腺癌细胞的增殖、凋亡、侵袭和转移,并且在乳腺癌的临床诊断和预后预测方面具有新的生物标志物的潜力,为乳腺癌的临床靶点治疗提供了新途径和新方法,在降低耐药性和增强药物敏感性等方面,有着重要的价值和应用前景。本文综述了miRNA在乳腺癌的分子机制、临床诊断、预后预测、临床靶点治疗等方面的研究进展,并对未来的研究方向提出了建议和展望。

MicroRNAs(miRNAs)are non-coding single-stranded RNA molecules whose role in breast cancer has been gradually discovered and clinically recognized and valued.MiRNAs play a role in the regulation of related target genes and signaling pathways in breast cancer,and participate in the proliferation,apoptosis,invasion and metastasis of breast cancer cells,and have new biomarker potential in clinical diagnosis and prognosis of breast cancer.It provides new ways and methods for the clinical treatment of breast cancer,and has important value and application prospects in reducing drug resistance and enhancing drug sensitivity.This article reviews the research progress of miRNAs in the molecular mechanism,clinical diagnosis,prognosis and clinical target treatment of breast cancer,and puts some suggestions and forward for future research directions.