Suxiao Jiuxin Pill intervened myocardium blood-supplying in moderate coronary stenosis patients with blood stasis syndrome by gated myocardial Perfusion imaging: a randomized controlled Trial

Objective To study the effect of Suxiao Jiuxin Pill on myocardium blood-supplying in moderate coronary stenosis patients with blood stasis syndrome by gated myocardial perfusion imaging.Methods Totally 101 moderate coronary stenosis blood stasis syndrome patients with anterior descending branch lesion and multi branches lesions were randomly assigned to treatment group and control group according to the table of random numbers from Jan 2010 to Dec 2013 in department of cardiology,Guang'anmen Hospital.According to different blood vessels lesions,the treatment group and control group were divided into anterior descending branch subgroup and multi-branch lesions subgroup respectively.The treatment group,54 patients,took 100 mg asplin every day and Suxiao Jiuxin Wan,5 pills every time,three times per day.The control group,47 patients,took 100 mg asplin every day and dini-trosorbide 10 mg every time,three times per day.The course of treatment was 6 months.Gated myocardial perfusion imaging evaluated myocardium blood-supply for 17 districts of heart ventricle.Results In multi-branch lesions subgroup of the control group,myocardium blood-supplying in 7(Medial anterior wall of left ventricle),13(apex anterior wall of left ventricle),14(apical septum of left ventricle)districts decreased after treatment(P<0.05).In multibranch lesions subgroup of treatment group,myocardium blood-supplying in 13,14,16(apical lateral wall of left ventricle),17(apex of left ventricle)districts decreased after treatment(P<0.01).In anterior descending branch subgroup of treatment group,myocardium bloodsupplying in 11(middle inferior wall of left ventricle)districts increased after treatment(P<0.05).Compared with the same subgroup,myocardium blood-supplying in 16 districts decreased in multi-branch lesions subgroup of treatment group(P<0.01).Conclusion Suxiao Jiuxin Pill can increase middle inferior wall of left ventricle myocardium blood-supply in anterior descending branch lesion moderate coronary stenosis patients.For multi-branches lesions moderate coronary stenosis patients,Suxiao Jiuxin Pill and dinitrosor-bide both can not increase the myocardium blood-supplying.